Method of treating bone metastasis

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C514S081000, C514S082000

Reexamination Certificate

active

07148210

ABSTRACT:
The invention provides a drug combination for the treatment of diseases associated with bone metastasis. The combination provides adenosine or a derivative thereof, a bisphosphonate, and a targeting agent(s) to decrease the signs or symptoms associated with such diseases.

REFERENCES:
patent: 4291024 (1981-09-01), Turcotte
patent: 4880918 (1989-11-01), Rapaport
patent: 5049372 (1991-09-01), Rapaport
patent: 5641500 (1997-06-01), Trepel et al.
patent: 2003/0004140 (2003-01-01), Dalton et al.
patent: 2005/0130922 (2005-06-01), Altaba et al.
Bolger et al., “Strontium-89 (Metastron) Versus External Beam Radiotherapy in Patients With Painful Bone Metastases Secondary to Prostatic Cancer:Preliminary Report of a Multicenter Trial”, Seminars in Oncology 1993 20 (3) (Supplemental 2) :32-33.
Elomaa et al., “Disphosphonates for Osteolytic Metastases”, Lancet 1985 vol. 1 (8438) :1155-1156.
Fishman et al., “Adenosine and Other Low Molecular Weight Factors Released by Muscle Cells Inhibit Tumor Cell Growth1”, Cancer Research 1998 58:3181-3187.
Estrela et al., “Elimination of Ehrlich tumours by ATP-induced growth inhibition, glutathione depletion and X-rays”, Nature Medicine 1995 1(1):84-88.
Fang et al., “P2-Purinergic Receptor Agonists Inhibit the Growth of Androgen-independent Prostate Carcinoma Cells”, J. Clin. Invest. 1992 89:191-196.
Galmarini et al., “Nucleotide analogues and nucleobases in cancer treatment”, Lancet Oncol. 2002 3:415-424.
Janssens and Boeynaems, “Effects of extracellular nucleotides and nucleosides on prostate carcinoma cells”, Br. J. Pharmacol. 2001 132:536-546.
Maymon et al., “Enhancing effect of ATP on intracellular adriamycin penetration in human ovarian cancer cell lines”, Biochimica et Biophysica Acta 1994 1201:173-178.
Mure et al., “Modulation of Membrane Permeability, Cell Proliferation and Cytotoxicity of Antitumor Agents by External ATP in Mouse Tumor Cells”, Jpn J. Cancer Res. 1992 83:121-126.
Rapaport et al., “Growth Inhibition of Human Tumor Cells in Soft-Agar Cultures by Treatment with Low Levels of Adrenosine 5′-Triphosphate”, Cancer Research 1983 43:4402-4406.
Rapaport Eliezer, “Treatment of Human Tumor Cells With ADP or ATP Yields Arrest of Growth in the S Phase of the Cell Cycle”, J. Cell Physiol. 1982 114(3) :279-283.
Robinson Ralph G., M.D., “Strontium-89-Precursor Targeted Therapy for Pain Relief of Blastic Metastatic Disease”, Cancer 1993 72:3433-3435.
Schroder and Rapaport, “Retinoic Acid Alters Subcellular Compartmentalization of ATP Pools in 3T3 Cells but Not in HeLa Cells”, J. Cell Physiol. 1984 120(2) :204-210.
van Holten-Verzantvoort et al., “Reduced Morbidity from Skeletal Metastases in Breast Cancer Patients During Long-Term Bisphosphonate (APD) Treatment”, Lancet 1987 2(8566) 983-.
von Albertini et al., “Extracellular ATP and ADP Activate Transcription Factor NF-KB and Induce Endothelial Cell Apoptosis”, Biochem. Biophys. Res. Commun. 1998 248 (3) :822-829.
von Albertini et al., “Adenosine Nucleotides Induce E-Selectin Expression in Porcine Endothelial Cells”, Transplant Proc. 1997 29(1-2) :1062.

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