Optics: measuring and testing – By dispersed light spectroscopy – With raman type light scattering
Reexamination Certificate
2006-12-12
2006-12-12
Lauchman, Layla G. (Department: 2877)
Optics: measuring and testing
By dispersed light spectroscopy
With raman type light scattering
C356S317000
Reexamination Certificate
active
07148963
ABSTRACT:
A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to traditional confocal Raman probes. The inventive probe collects spectra from an area or 1 mm or greater, preferably 3–12 mm or more, compared to current instruments which utilize spot sizes on the order of 2–60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.
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Zhiwei Huang, Haishen Zeng, Iltefat Hamzavi, David I. McLean, and Harvey Lui, “Rapid near-infrared Raman spectroscopy system for real-time in vivo skin measurements,” Optic Letters, vol. 26, No. 22, Nov. 15, 2001.
Owen Harry
Slater Joseph B.
Strachan David J.
Tedesco James M.
Gifford Krass Groh Sprinkle Anderson & Citkowski PC
Kaiser Optical Systems
Lauchman Layla G.
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