Prognostic methods for breast cancer

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07056663

ABSTRACT:
Methods of determining the likelihood of the re-occurrence of tumors and of determining the aggressiveness of post-surgical treatment are provided which rely on analysis of a loss of heterogeneity at the particular chromosomal locus 3p24.3. Loss of expression or hypermethylation of the thyroid hormone receptor β1 gene is also predictive of an increased re-occurrence of tumors.

REFERENCES:
patent: 2001/0039015 (2001-11-01), Sauter
patent: 2002/0055096 (2002-05-01), Deng et al.
patent: WO 98/17828 (1998-04-01), None
Deng et al. Loss of Heterozygosity in Normal Tissue Adjacent to Breast Carcinomas. Science, vol. 274, pp. 2057-2059, Dec. 1996.
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Matsumoto, Satoshi, et al., “Detailed Deletion Mapping of Chromosome Arm 3p in Breast Cancers: A 2-cM Region on 3p14.3-21.1 and a 5-cM Region on 3p24.3-25.1 Commonly Deleted in Tumors,”Genes, Chromosomes and Cancer, 1997, pp. 268-274, vol. 20.
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