Physiologically active peptide and its use

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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Reexamination Certificate

active

07064181

ABSTRACT:
The present invention relates to a peptide comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 35 and having an ability of binding to a receptor protein comprising an amino acid sequence identical to or substantially identical to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 2 or SEQ ID NO: 3, or a precursor thereof, its amide or ester, or a salt thereof.An inventive peptide-encoding DNA or equivalent can be employed in (1) a development of a receptor binding assay system using an expression system of a recombinant receptor protein and a screening for a pharmaceutical candidate compound, and (2) a development of a pharmaceutical having a reduced side effect such as a memory function improving agent, a appetite improving agent, an uterine, renal, prostatic, testicular or skeletal muscle function regulating agent.

REFERENCES:
patent: 5576296 (1996-11-01), Bartfai et al.
patent: WO 92/12997 (1992-08-01), None
patent: WO 92/20709 (1992-11-01), None
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S. Wang et al., “Cloning and Expressional Characterization of a Novel Galanin Receptor”, The Journal of Biological Chemistry, vol. 272, No. 51, PP.31949-31952(1997).
K. Smith et al., “Cloned Human and Rat Galanin GALR3 Receptors”, The Journal of Biological Chemistry, vol. 273, No. 36, PP. 23321-23326(1998).

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