Inhibition of TNF-α-initiated neutrophil response

Details Inhibition of TNF-α-initiated neutrophil response Inhibition of TNF-α-initiated neutrophil response

2006-11-07

2006-11-07

Jones, Dwayne (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

C514S213010, C514S224200, C514S219000, C514S552000, C514S558000

Reexamination Certificate

active

07132451

ABSTRACT:
The impact of lipoxin A4(LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFα)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as 1–10 nM, the LXA4and ATL analogs each inhibited TNFα-stimulated superoxide anion generation and IL-1β release by human PMN.

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