Cytotoxic assay and new established cell line of sturgeon...

Details Cytotoxic assay and new established cell line of sturgeon... Cytotoxic assay and new established cell line of sturgeon...

2006-11-07

2006-11-07

Tate, Christopher R. (Department: 1655)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Reexamination Certificate

active

07132230

ABSTRACT:
An object of the present invention is to provide a cytotoxic assay using a new established fish cell line. The invention attained according to the object is a cytotoxic assay, wherein an evaluation of toxicity of a specimen is performed on the basis of its toxicity to an established cell line originated from sturgeon, preferably a STIP-1 cell line (FERM BP-8421) and a STIP-3 cell line (FERM BP-8422). Furthermore, another object of the present invention is to provide a new established cell line expected to be used in the diagnosis of viral infection disease of sturgeon and so on. The invention attained according to the object is an established cell line originated from a sturgeon eyeball, particularly a STIP-1 cell line (FERM BP-8421) and a STIP-3 cell line (FERM BP-8422).

REFERENCES:
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Fent, K, “Fish cell lines as versatile tools in ecotoxicology: assessment of cytotoxicity, cytochrome P4501A induction potential and estrogenic activity of chemicals and environmental samples” (Toxicology in Vitro) 2001. Col. 15, pp. 477-488.
Hiramatsu et al. “Vitellogenin-derived yolk proteins in a hybrid sturgeon, bester: Identification, characterization & course of proteolysis during embryogenesis” (Comparative Biochemistry & Physiology) 2002. vol. 131, pp. 429-441.
Babich et al. “Fathead Minnow FHM Cells for Use in Vitro Cytotoxicity Assays of Aquatic Pollutants” (Ecotoxicology and Environmental Safety) 1987. Col. 14, pp. 78-87.
S. Magwood et al., “In VitroAlternatives to Whole Animal Testing. Comparative Cytotoxicity Studies of Divalent Metals in Established Cell Lines Derived From Tropical and Temperate Water Fish Species in a Neutral Red Assay”,Marine Environmental Researchvol. 42, No. 1-4, pp. 37-40, 1996.
H. Babich et al., “In VitroCytotoxicity Testing of Aquatic Pollutants (Cadmium, Copper, Zinc, Nickel) Using Established Fish Cell Lines”,Ecotoxicology and Environmental Safety11, pp. 91-99, 1986.
Ronald P. Hedrick, “Two Cell Lines from White Sturgeon”,Transactions of the American Fisheries Society120: 528-534, 1991.
M.F. Li et al., “Fish cell culture: two newly developed cell lines from Atlantic sturgeon (Acipenser oxyrhynchus) and guppy (Poecilia reticulata)”,Canadian Journal of Zoology63: 2867-2874, 1984.

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