Methods of administering and enhancing absorption of...

Details Methods of administering and enhancing absorption of... Methods of administering and enhancing absorption of...

2006-08-08

2006-08-08

Padmanabhan, Sreenivasin (Department: 1616)

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

C424S046000, C424S434000, C424S455000, C424S464000, C514S002600, C514S003100, C514S866000, C514S946000

Reexamination Certificate

active

07087215

ABSTRACT:
Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for administering the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth, which has been demonstrated to achieve peak plasma levels of the pharmaceutical agent in about thirty minutes.

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