Synthesis of nicotine derivatives from nicotine

Details Synthesis of nicotine derivatives from nicotine Synthesis of nicotine derivatives from nicotine

2006-11-07

2006-11-07

Aulakh, Charanjit S. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S279400

Reexamination Certificate

active

07132545

ABSTRACT:
Methods of synthesizing nicotine analogs and derivatives are described. In some embodiments the methods utilize an alkyl or aryl silyl-substituted nicotine analog intermediate. Intermediates useful for the synthesis of nicotine and nicotine analogs are also described.

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Brown, et al. A Convenient Synthesis of Dimethyl (Diazomethyl)phosphate (Seyferth/Gilbert Reagent).J. Org. Chem.61:2540-2541 (1996).
Kondo, et al. TMP-Zincate as Highly Chemoselective Base for Directed Ortho Methylation.J. Am. Chem. Soc.121:3539-3540 (1999).

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