Method of induction of apoptosis and inhibition of matrix...

Details Method of induction of apoptosis and inhibition of matrix... Method of induction of apoptosis and inhibition of matrix...

2006-02-21

2006-02-21

Pak, John (Department: 1616)

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

C424S400000, C424S402000, C424S404000, C424S405000, C424S443000, C424S445000, C424S447000, C424S489000, C424S490000, C424S619000, C424S646000, C424S649000, C514S492000, C514S495000, C514S825000, C514S878000, C514S951000, C514S964000

Reexamination Certificate

active

07001617

ABSTRACT:
The invention relates to a method to induce apoptosis and to inhibit matrix metalloproteinases in a disease condition in a human or animal by contacting hyperplastic tissue, tumor tissue, or a cancerous lesion with one or more antimicrobial metals, preferably formed with atomic disorder, and preferably in a nanocrystalline form. In another aspect of the invention, there is provided a method of preventing excessive release of matrix metalloproteinases from an inflammatory cell in a disease condition in a human or an animal by contacting the cell with a therapeutically effective amount of a noble metal in a crystalline form characterized by atomic disorder, or with a solution derived therefrom to provide a modulatory effect on one or more matrix metalloproteinases, wherein the one or more noble metals is formed with atomic disorder, and preferably in a nanocrystalline form. The nanocrystalline antimicrobial or noble metal of choice may be used in the form of a nanocrystalline coating of one or more antimicrobial or noble metals, a nanocrystalline powder of one or more antimicrobial or noble metals, or a solution containing dissolved species from a nanocrystalline powder or coating of one or more antimicrobial or noble metals.

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