Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-06-13
2006-06-13
Wax, Robert A. (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S252300, C435S254110, C435S320100, C435S325000, C536S023500
Reexamination Certificate
active
07060464
ABSTRACT:
The present invention relates to peptides comprising at least one sequence selected from the group consisting of oligopeptide sequences of at least about 10 but not more than about 50 continuous amino acid residues in the amino acid sequence of the C-terminal acidic tail (ATS), which can render fusion partner proteins environmental stress resistant by binding thereto while conserving their intrinsic properties. Also, it relates to fusion proteins formed by binding the above peptides to fusion partner proteins, nucleotide sequences encoding said fusion proteins, recombinant vectors comprising said nucleotide sequences, and cells transformed or transfected with said recombinant vectors. In addition, it relates to processes for producing the above environmental stress resistance conferring peptides or environmental stress resistant fusion proteins by chemical synthesis or genetic recombination.
REFERENCES:
patent: 2002/0048763 (2002-04-01), Penn et al.
Kanda et al., “Enhanced Vulnerability to Oxidative Stress by alpha-synuclein□□Mutations and C-Terminal Truncation,” Neuroscience, 2000, 97(2):279-284.
Kim et al., “Structural Changes in alpha-synuclein Affect its Chaperone-like□□Activity in vitro,” Protein Science, 2000, 9:2489-2496.
Kim et al., “Thermal Behavior of Proteins: Heat-Resistant Proteins and Their Heat-□□Induced Secondary Structural Changes,” Biochemistry, 2000, 39:14839-14846.
Souza et al., “Chaperone-like Activity of Synucleins,” FEBS Letters, 2000, 474:116-119.
Atgen Co., Ltd.
JHK Law
Kim Joseph Hyosuk
Wax Robert A.
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