Screening methods based on isolating a collection of...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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Reexamination Certificate

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07097978

ABSTRACT:
Methods for assessing potential pharmacological effects and/or side effects of an agent, based on the effect of the agent on the distribution and properties of accessible regions in cellular chromatin, are provided.

REFERENCES:
patent: 5176996 (1993-01-01), Hogan et al.
patent: 5422251 (1995-06-01), Fresco
patent: 5436142 (1995-07-01), Wigler et al.
patent: 5501964 (1996-03-01), Wigler et al.
patent: 5525471 (1996-06-01), Zeng
patent: 5585245 (1996-12-01), Johnsson et al.
patent: 5695937 (1997-12-01), Kinzler et al.
patent: 5789538 (1998-08-01), Rebar et al.
patent: 5866330 (1999-02-01), Kinzler et al.
patent: 5935830 (1999-08-01), Meyer, Jr. et al.
patent: 5958738 (1999-09-01), Lindemann et al.
patent: 5998140 (1999-12-01), Dervan et al.
patent: 6007988 (1999-12-01), Choo et al.
patent: 6013453 (2000-01-01), Choo et al.
patent: 6090947 (2000-07-01), Dervan et al.
patent: 6218128 (2001-04-01), Klein et al.
patent: 2002/0045158 (2002-04-01), Case
patent: 2003/0170689 (2003-09-01), Stamatoyannapoulos et al.
patent: 2004/0234985 (2004-11-01), Weinzierl
patent: WO 93/06121 (1993-04-01), None
patent: WO 94/08051 (1994-04-01), None
patent: WO 95/12608 (1995-05-01), None
patent: WO 95/19431 (1995-06-01), None
patent: WO 95/30642 (1995-11-01), None
patent: WO 95/35503 (1995-12-01), None
patent: WO 98/44350 (1998-08-01), None
patent: WO 98/53057 (1998-11-01), None
patent: WO 98/53058 (1998-11-01), None
patent: WO 98/53059 (1998-11-01), None
patent: WO 98/53060 (1998-11-01), None
patent: WO 98/54311 (1998-12-01), None
patent: WO 99/45132 (1999-09-01), None
patent: WO 99/47656 (1999-09-01), None
patent: WO 99/48909 (1999-09-01), None
patent: WO 00/23464 (2000-04-01), None
patent: WO 00/42219 (2000-07-01), None
patent: WO 0041566 (2000-07-01), None
Antequera et al., “Specific Protection of Methylated CpGs In Mammalian Nuclei,”Cell58:509-517 (1989).
Bird, “The Essential of DNA Methylation,”Cell70:5-8 (1992).
Bird et al., “Methylation-Induced Repression-Belts, Braces, and Chromatin,”Cell99:451-454 (1999).
Bitko & Barik, “Persistant Activation of Re1A by Respiratory Syncytial Virus Involes Protein Kinase C, Underphosphorylated IκBβ, and Sequestration of Protein Phosphate 2A by the Viral Phosphoprotein,”Journal of Virology72(7):5610-5618 (1998).
Bringmann et al., “Antibodies Specific forN6-Methyladenosine React with Intact snRNPs U2 and U4/U6,”FEBS213(2):309-315 (1987).
Cantley, “Translocating Tubby,”Science292:2019-2020 (2001).
Caron and Hamilton, Developmentally Specific Effects of the DNA Cross . . . , Dec. 1997, pp. 325-337.
Cartwright et al., “Cleavage of Chromatin with Methidiumpropyl-EDTA-iron(II),”Proc. Natl. Acad. Sci. U.S.A.80:3213-3214 (1983).
Chern et al., “The Regulator of MAT2(ROM2) Proteins Binds to Early Maturation Promoters and Represses PvALF-Activated Transcription,”Plant Cell8:305-621 (1996).
Cheung et al., “Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation,”Molecular Cell5:905-915 (2000).
Cho et al., “Analysis of the C-Terminal Region ofArabidopsis ThalianaAPETALA1 as a Transcription Activation Domain,”Plant Mol. Biol.40:419-429 (1999).
Collingwood et al., “Nuclear Receptors: Coactivators, Corepressors and Chromatin Remodeling in the Control of Transcription,”J. Mol. Endocrinol.23:255-275 (1999).
Darnell, “Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins,”Science264:1415-1421 (1994).
Darnell, “STATS and Gene Regulation,”Science277:1630-1635 (1997).
Doyle & Hunt, “Reduced Nuclear Factor κB (p. 65) Expression in Rat Primary Sensory Neurons After Peripheral Nerve Injury,”Neuroreport8(13):2937-2942 (1997).
Eichelbaum, M. et al., “Influence of Pharmacogentics on Drug Disposition and Response,”Clin. EP. Pharmacol. Physiol.23(10-11):983-985 (1996).
Fields et al.,“A Novel Genetic System to Detect Protein-Protein Interactions,”Nature340:245-246 (1989).
Garrington et al., “Organization and Regulation of Mitogen-Activated Protein Kinase Signaling Pathways,”Current Opin. Cell Biol.11:211-218 (1999).
Gilmour et al., “Detecting Protein-DNA Interactionsin vivo. Distribution of RNA Polymerase on Specific Bacterial Genes,”Proc. Natl. Acad. Sci. U.S.A.81:4275-4279 (1984).
Goff et al.,“Identification of Functional Domains in the Maize Transcriptional Activator C1: Comparison of Wild-Type and Dominant Inhibitor Proteins,”Genes Dev.5:298-309 (1991).
Gong et al., “A Constitutively Expressed Myc-Like Gene Involved in Anthocyanin Biosynthesis fromPerilla frutescens: Molecular Characterization, Heterlogous Expression in Transgenic Plants and Transactivation in Yeast Cells,”Plant Molecular Biology41:33-44 (1999).
Gould Rothberg et al., “Integrating Expression-Based Drug Response and SNP-Based Pharmacogenetic Strategies Into a Single Comprehensive Pharmacogenomics Program,”Drug Development Research49:54-64 (2000).
Greene et al., “Sequence of the Bacteriophage SP01 Gene Coding for Transcription Factor 1, a Viral Homologue of the Bacterial Type II DNA-Binding Proteins,”Proc. Natl. Acad. Sci. U.S.A.81:7031-7035 (1984).
Greisman et al., “A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites,”Science275:657-661 (1997).
Gross & Garrard, “Nuclease Hypersensitive Sites in Chromatin,”Annual Review of Biochemistry57:159-197 (1988).
Gutkind, “The Pathways Connecting G Protein-coupled Receptors to the Nucleus Through Divergent Mitogen-activated Protein Kinase Cascades,”J. Biol. Chem.273:1839-1842 (1998).
Hagman et al., “The VP16 Paradox: Herpes Simplex Virus VP16 Contains a Long-Range Activation Domain but Within the Natural Multiprotein Complex Activates Only from Promoter-Proximal Positions,”Journal of Virology71(8):5952-5962 (1997).
Hendrich et al., “Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins,”Molecular and Cellular Biology18(11):6538-6548 (1998).
Hershkovitz and Riggs, “Ligation-Mediated PCR for Chromatin-Structure Analysis of Interphase and Metaphase Chromatin,”METHODS: A Companion in Methods in Enzynology11:253-263 (1997).
Hertzberg et al., “Cleavage of DNA with Methidiumpropyl-EDTA-Iron(II): Reaction Conditions and Product Analyses,”Biochemistry23:3934-3945 (1984).
Hobo et al., “A bZIP Factor, TRAB1, Interacts with VP1 and Mediates Abscisic Acid-Induced Transcription,”Proc. Natl. Acad. Sci. U.S.A.96(15):15348-15353 (1999).
Ihle, “STATs: Signal Transducers and Activators of Transcription,”Cell84:331-334 (1996).
Ihle, “Signaling by the Cytokine Receptor Superfamily in Normal and Transformed Hematopoietic Cells,”Advances in Cancer Research68:23-65 (1996).
Iyer et al., “The Transcriptional Program in the Response of Human Fibroblasts to Serum,”Science283:83-87 (1999).
Jamieson et al., “In Vitro Selection of Zinc Fingers with Altered DNA-Binding Specificity,”Biochemistry33(19):5689-5695 (1994).
Jamieson et al., “A Zinc Finger Directory for High-Affinity DNA Recognition,”Proc. Natl. Acad. Sci. U.S.A.93:12834-12839 (1996).
Jones et al., “Cancer Epigenetics Comes of Age,”Nature Genet.21:163-167 (1999).
Joung et al.,“A Bacterial Two-Hybrid Selection System for Studying Protein-DNA and Protein-Protein Interactions,”Proc. Natl. Acad. Sci. U.S.A.97:7382-7387 (2000).
Kamei et al., “A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors,”Cell85:403-414 (1996).
Kimura et al.,“On the DNA Binding Protein II FromBacillus Stearothermophilus,” The Jorunal of Biological Chemistry258(6):4007-40

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