Mass spectrometry system

Details Mass spectrometry system Mass spectrometry system

2006-10-24

2006-10-24

Berman, Jack (Department: 2881)

Radiant energy

Ionic separation or analysis

C250S281000, C250S282000, C250S288000

Reexamination Certificate

active

07126113

ABSTRACT:
According to the existing mass spectrometric system, whether or not the informations are sufficient for analyzing substances (particularly proteins, sugars, etc.) cannot be judged in the process of measurement. Further, it is difficult to find out isomers having just the same mass number or compounds very close in mass only from the MS data. According to this invention, whether or not the retention time in the LC (or GC) of peptide formed at the time of enzymatic decomposition of protein coincides with the predicted retention time assumed from the amino acid sequence predicted from MS2mass spectrometry data is judged within the actual time period of measurement, and thereby the quality of MS2mass spectrometry data (quantity of information) is judged.

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Wysocki, Vicki, H., et al. “Mobile and localized protons: a framework for understanding peptide dissociation.” Journal of Mass Spectrometry, 35, 2000, pp. 1399-1406.
Meek, James, L. “Prediction of peptide retention times in high-pressure liquid chromatography on the basis of amino acid composition,” Proc. Natl. Acad. Sci. USA 77, 1980, pp. 1632-1636.

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