Substituted arylamides as IP antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S300100, C548S347100, C548S348100

Reexamination Certificate

active

06998414

ABSTRACT:
Compounds effective as IP receptor modulators, particularly IP receptor antagonists, that are of the formula I:wherein A, R1, R2, R3and R4are as defined in the specification; and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. Also disclosed are pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

REFERENCES:
patent: 4396617 (1983-08-01), Dolman et al.
patent: 5741796 (1998-04-01), Hartman et al.
patent: 6184242 (2001-02-01), Bley et al.
patent: 6417186 (2002-07-01), Jahangir
patent: 0017484 (1980-10-01), None
patent: 0 902 018 (1998-03-01), None
patent: WO 00/72840 (2000-12-01), None
patent: WO 02/40453 (2002-05-01), None
LeClerc, Gerard et al., Agents alpha-adrenergiques alcoylants, European Journal of Medicine, 1983-18, No. 4, pp. 379-383.

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