Ex vivo generation of functional leukemia cells in a...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Solid support and method of culturing cells on said solid...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S399000, C435S375000, C435S383000, C435S385000

Reexamination Certificate

active

07087431

ABSTRACT:
The present invention provides cultured leukemia cells. The method comprises isolating mononuclear cells, which contain leukemia cells, culturing the leukemia cells in a chamber having a scaffolding covered or surrounded with culture medium, where the scaffolding allows for leukemia cells to have cell to cell contacts in three dimensions. The subject leukemia cells are useful for screening compounds which inhibit or stimulate leukemia cell function or formation.

REFERENCES:
patent: 5459069 (1995-10-01), Palsson et al.
patent: 5478739 (1995-12-01), Slivka et al.
patent: 5496722 (1996-03-01), Goodwin et al.
patent: 5512480 (1996-04-01), Sandstrom et al.
patent: 5541107 (1996-07-01), Naughton et al.
patent: 5578485 (1996-11-01), Naughton et al.
patent: 5719058 (1998-02-01), Rodan et al.
patent: 5827729 (1998-10-01), Naughton et al.
patent: 5830708 (1998-11-01), Naughton
patent: 5855608 (1999-01-01), Brekke et al.
patent: 5856186 (1999-01-01), Rodan et al.
patent: 6093533 (2000-07-01), Rodan et al.
patent: 5-192178 (1993-08-01), None
patent: 6-46877 (1994-02-01), None
patent: 9-59174 (1997-03-01), None
patent: 11-9269 (1999-01-01), None
patent: WO 87/06120 (1987-10-01), None
patent: WO 93/07271 (1993-04-01), None
patent: WO 01/12785 (2001-02-01), None
Vunjak-Novakovi, et al. Biotechnol Prog. 1998, 14:193-202.
Rummel, et al., 1994, J Hematother, 3(3):213-8.
Liu, et al, 1991, Cytotehcnology, 5(2):129-39.
Visani, et al. 1994, Leukemia, 8(12):2183-87.
Tsunogake, et al., 1991, Int J Immunotherapy, 7(2):63-72.
Jiang et al (Aug. 1, 1998, Blood, vol. 92, pp. 834-841).
Vassiliadis (1994, Haematologia, vol. 26, pp. 29-37,abstract only).
Eaves et al (1993, Leuk Lymphoma, vol. 11, Suppl 1, pp. 259-263, abstract only).
Merriam-Webster Online Dictionary downloaded from URL > m-w.com on Jul. 24, 2003.
Vassiliadis (1994, Haematologia, vol. 26, pp. 29-37, entire article with this Action).
Lange (1989, Cell growth and division, a practical approach, Baserga, R. ed., IRL Press, Chapter 4, pp. 61-76.
Chen et al (1997, Biochim Biophys Acta, vol. 1358, pp. 200-208, abstract only).
Merriam-Webster Online Dictionary (down loaded from url>>m-w.com on Mar. 21, 2004) for semisynthetic.
Definition of “particle” in Merriam-Webster Online dictionary downloaded from URL>>www.m-w.com on Nov. 21, 2004, p. 1 only of 2.
Definition of “porous” in Merriam-Webster Online dictionary downloaded from URL>>www.m-w.com on Nov. 21, 2004, p. 1 only of 2.
Gloeckner et al., “Hollow-Fiber Bioreactor System for the Expansion of Activated Human T-Cells in High Densities,”Blood96(11)(Part 1):776a (2000) (abstract only).
Visani et al., All-trans Retinoic Acid Potentiates Megakaryocyte Colony Formation:In VitroandIn VivoEffects After Administration to Acute Promyelocytic Leukemia Patients,Leukemia8(12):2183-2187 (1994).
Schwarzmeier et al., “Myelosuppression in HCL: Role of Hairy Cells, T Cells and Haematopoietic Growth Factors,”Eur. J. Heamatology52(5):257-262 (1994).
Tsunogake et al., “Differential Effects of Ubenimex on Growth of Normal Human Haematopoietic Progenitors and Leukaemic CellsIn Vitro,”International Journal Immunotherapy7(2):63-72 (1991).
Applebaum, F.R., “Molecular Diagnosis and Clinical Decisions in Adult Acute Leukemia,”Seminars in Hematology36(4):401-410 (1999).
Lange, B.J., “Growth of Human Leukaemia Cellsin vitro,” inCell Growth and Division—A Practical Approach, Chapter 4, Baserga, Renato, ed., Oxford, NY: IRL Press at Oxford University Press, pp. 61-79 (1989).
Naughton et al., “A Three-Dimensional Culture System for the Growth of Hema-Topoietic Cells,”Bone Marrow Purging and Processing333:435-445 (1990).
Naughton et al., “Hematopoiesis on Suspended Nylon Screen-Stromal Cell Microenvironments,”Journal of Biomechanical Engineering113:171-177 (1991).
Tjota et al., “Stromal Cells Derived from Spleen or Bone Marrow Support the Proliferation of Rat Natural Killer Cells in Long-Term Culture,”Proc. Soc. Exp. Biol. Med. 200(3):431-441 (1992).
Naughton et al., “Differential Effects of Drugs Upon Hematopoiesis Can Be Assessed in Long-Term Bone Marrow Cultures Established on Nylon Screens,”Proc. Soc. Exp. Biol. Med. 199(4):481-90 (1992).
Naughton et al., “Hematopoiesis on Nylon Mesh Templates. Comparative Long-Term Bone Marrow Culture and the Influence of Stromal Support Cells,”Ann. N.Y. Acad. Sci. 554:125-40 (1989).
Naughton et al., “Hematopoiesis on Nylon Mesh Templates. I. Long-Term Culture of Rat Bone Marrow Cells,”Journal of Medicine, 18(3, 4):219-250 (1987).
Benayahu et al., “Mineralization of Marrow-Stromal Osteoblasts MBA-15 on Three-Dimensional Carriers,”Calcif. Tissue Int. 55:120-127 (1994).
Ishaug et al., “Bone Formation by Three-Dimensional Stromal Osteoblast Culture in Biodegradable Polymer Scaffolds,”J. Biomed. Materials Res. 36:17-28 (1997).
Rosenzweig et al., “Enhanced Maintenance and Retroviral Transduction of Primitive Hematopoietic Progenitor Cells Using a Novel Three-Dimensional Culture System,”Gene Therapy4:928-936 (1997).
Salisbury et al., “Three-Dimensional Reconstruction of Non-Hodgkin's Lymphoma in Bone Marrow Trephines,”J. Pathol. 181:451-454 (1997).
Glowacki et al., “Perfusion Enhances Functions of Bone Marrow Stromal Cells in Three-Dimensional Culture,”Cell Transplantation, 7(3):319-326 (1998).
Martin et al., “In VitroDifferentiation of Chick Embryo Bone Marrow Stromal Cells into Cartilaginous and Bone-Like Tissues,”J. Orthopaedic Res. 16:181-189 (1998).
Bagley et al., “Extended Culture of Multipotent Hematopoietic Progenitors Without Cytokine Augmentation in a Novel Three-Dimensional Device,”Experi. Hematology27(3):496-504 (1999).
Dexter et al., “Proliferation of Haemopoietic Stem CellsIn Vitro,”Brit. J. Haematol. 28:525-530 (1974).
Fluckiger et al., “In VitroReconstitution of Human B-Cell Ontogeny: From CD34+ Multipotent Progenitors to IG-Secreting Cells,”Blood92(12):4509-4520 (1998).
Mantalaris et al., “Engineering a Human Bone Marrow Model: A Case Study onEx VivoErythropoiesis,”Biotechnology Progress14(1):126-133 (1998).
Poznansky et al., “Efficient Generation of Human T Cells from a Tissue-Engineered Thymic Organoid,”Nature Biotechnology18(7):729-734 (2000).
Pollack, S.B., “Production and Differentiation of NK Lineage Cells in Bone Marrow,”Nat. Immun. 12:177-193 (1993).
Porter et al., “A Tissue of T Cells,”Nature Biotechnology18(7):714-715 (2000).
Slovick et al., “Survival of Granulocytic Progenitors in the Nonadherent and the Adherent Compartments of Human Long-Term Bone Marrow Cultures,”Experimental Hematology12:327-338 (1984).
Wang et al., “Multilineal Hematopoiesis in a Three-Dimensional Murine Long-Term Bone Marrow Culture,”Experimental Hematology23:26-32 (1995).
Whitlock et al., “Murine B Cell Lymphopoiesis in Long Term Culture,”J. Immunological Methods67:353-369 (1984).
Whitlock et al., “Long-Term Culture of B Lymphocytes and Their Precursors from Murine Bone Marrow,”Proc. Natl. Acad. Sci USA79:3608-3612 (1982).
Flanagan, A.M., “An Assessment of the Ability of Human Bone Marrow Cultures to Generate Osteoclasts,”Int. J. Exp. Path. 73:387-401 (1992).
Helfrich et al., “Osteoclast Generation From Human Fetal Bone Marrow in Cocultures with Murine Fetal Long Bones,”Cell and Tissue Research249(1):125-136 (1987).
Horton et al., “Cell Surface Characterization of the Human Osteoclast: Phenotypic Relationship to Other Bone Marrow-Derived Cell Types,”J. Pathol. 144:281-294 (1984).
Kukita et al., “Osteoclast-Like Cells Formed In Long-Term Human Bone Marrow Cultures Express a Similar Surface Phenotype As Authentic Osteoclasts,”Laboratory Investigation60(4):532-538 (1989).
Lambrecht et al

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Ex vivo generation of functional leukemia cells in a... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Ex vivo generation of functional leukemia cells in a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ex vivo generation of functional leukemia cells in a... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3652092

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.