Solid-phase electrophilic fluorination

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

Reexamination Certificate

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C424S001110, C424S001650, C424S001810, C424S001850, C424S009100, C424S009300

Reexamination Certificate

active

07115249

ABSTRACT:
The invention relates to compounds of formula (I); wherein R1and R2independently selected from C1-6alkyl; P1, P2, P3, and P4are each independently hydrogen or a protecting group; and their use in the preparation of18F-labelled 6-L-fluorodopa

REFERENCES:
patent: 08067657 (1996-12-01), None
patent: WO9400460 (1994-06-01), None
Yun W, et.al. “Solid-phase synthesis of diaryl ketonoes through a three-component Stille coupling reaction” Tetrahedron Ltters, Elsevier Science Publishers, Amsterdam, NL, vol. 42, No. 2, Jan. 8, 2001 pp. 175-177.
Frank Forman, et.al. “Solid Phase Synthesis of Biaryls via the Stille Reaction” J. Org Chem., vol. 60, 1995, pp. 523-528.
Ding, et.al. “No-Carrier-Added (NCA) {18F} Fluorides via the nucleophilic Aromatic Substitution of Electron-Rich Aromatic Rings” J. Fluorine Chem., vol. 48, No. 2, 1990 pp. 189-205.

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