Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2006-11-21
2006-11-21
Wells, Nikita (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S281000, C250S290000, C250S292000
Reexamination Certificate
active
07138624
ABSTRACT:
Accurate mass measurement is carried out for product ions of a sample. A method for accurate mass determination of ions with Trap-TOF/μs includes steps of generating ions of an analyte sample and a standard material; introducing the ions of the analyte sample and the standard material together into an ion trap to trap them; selecting a precursor ion from the ions of the analyte sample to leave the precursor ion and a standard material ion in the ion trap and eliminate other ions; exciting and dissociating the precursor ion to generate product ions; ejecting the precursor ion, its product ions, and the standard material ion trapped in the ion trap to introduce these ions into the TOF mass spectrometer; and measuring a mass spectrum with the TOF mass spectrometer, where correction for accurate masses of the product ions is carried out based on the standard material ion measured.
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G. Hopfgartner et al., “Exact Mass Measurement of Product Ions for the Structural Elucidation of Drug Metabolites with a Tandem Quadrupole Orthogonal-Acceleration Time-of—Flight Mass Spectrometer,” Journal of America Society for Mass Spectrometry, 10 (1999), pp. 1305-1314.
No affiliations
Dickstein & Shapiro LLP
Hitachi High-Technologies Corporation
Souw Bernard E.
Wells Nikita
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