Beta-lactamase inhibitor prodrug

Details Beta-lactamase inhibitor prodrug Beta-lactamase inhibitor prodrug

2006-08-15

2006-08-15

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S310000

Reexamination Certificate

active

07091197

ABSTRACT:
Prodrugs of 6-β-hydroxymethylpenicillanic acid sulfone having the structurewherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of the present invention or a solvate thereof, an optional beta-lactam antibiotic and a pharmaceutically acceptable excipient.Further disclosed is a method for increasing the therapeutic effectiveness of a beta-lactam antibiotic in a mammal by administering an effective amount of a beta-lactam antibiotic and an effectiveness-increasing amount of a prodrug of the present invention, or a solvate thereof.Additionally disclosed is a method for treating a bacterial infection in a mammal by administering a therapeutically effective amount of a pharmaceutical composition of the present invention to a mammal in need thereof.

REFERENCES:
patent: 3719668 (1973-03-01), Frederiksen et al.
patent: 3862181 (1975-01-01), Davis et al.
patent: 3864331 (1975-02-01), Frederiksen et al.
patent: 3931405 (1976-01-01), Ekstrom et al.
patent: 3957764 (1976-05-01), Lund
patent: 4287181 (1981-09-01), Kellogg
patent: 4397783 (1983-08-01), Kellogg et al.
patent: 4406887 (1983-09-01), Gordon et al.
patent: 4428935 (1984-01-01), Myers
patent: 4432970 (1984-02-01), Kellogg
patent: 4521533 (1985-06-01), Hamanaka et al.
patent: 4540689 (1985-09-01), Muto et al.
patent: 5373018 (1994-12-01), Cugola et al.
patent: 5374648 (1994-12-01), Cugola et al.
patent: 5374649 (1994-12-01), Cugola et al.
patent: 5401868 (1995-03-01), Lund
patent: 2005/0004093 (2005-01-01), Marfat et al.
patent: 0379132 (1990-07-01), None
patent: 1267936 (1972-03-01), None
patent: 1315566 (1973-05-01), None
patent: 1377573 (1974-12-01), None
patent: 1426717 (1976-03-01), None
patent: 2053220 (1981-02-01), None
patent: 2076812 (1981-12-01), None
patent: 58049387 (1983-03-01), None
patent: 3206038 (1991-03-01), None
English, A. R., et al.,Orally Effective Acid Prodrugs of the β-Lactamase Inhibitor Sulbactam, J. Med. Chem., vol. 33, pp. 344-347, (1990).
Patent Abstracts of Japan, vol. 0154, No. 74 (C-0809), (1991), Abstract for JP3206038.
English language abstract for EP0379132.
English language abstract for JP58049387.

Affiliated with

Also associated with

Rating

Beta-lactamase inhibitor prodrug does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Beta-lactamase inhibitor prodrug, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Beta-lactamase inhibitor prodrug will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3649830