Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-06-08
2000-03-07
Ramsuer, Robert W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D49504
Patent
active
060342528
ABSTRACT:
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable salts thereof wherein wherein: R.sub.1, R.sub.2, and and R.sub.4 independenlty represent hydrogen, halogen, alkyl, cyano, alkoxycarbonyl, trifluoromethoxy, SO.sub.2 NH.sub.2 or trifluoromethyl;
R.sub.3 represents hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, amino, mono- or di(C.sub.1 -C.sub.6)alkylamino, cyano, alkoxycarbonyl, trifluoromethoxy, SO.sub.2 NH.sub.2 or trifluoromethyl; or
R.sub.3 represents optionally substituted phenyl;
X represents (CH.sub.2).sub.n where n is an integer; and
m is 0 or an integer,
which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.
REFERENCES:
Prim et al, Chemical Abstracts, vol. 124, No. 289154; CA Index Guide or Ring System Handbook, 1996.
Chen Xi
Wasley Jan W. F.
Neurogen Corporation
Ramsuer Robert W.
Sarussi Steven J.
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