Phenyl-alkyl-imidazoles

Details Phenyl-alkyl-imidazoles Phenyl-alkyl-imidazoles

1998-11-05

2000-03-07

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

5483411, 5483415, 5483421, 514399, 514400, C07D23354, C07D23360, C07D23361, C07D23390, A61K 31415

Patent

active

06034251&

ABSTRACT:
Disclosed are novel phenyl-alkyl-imidazoles of the formula ##STR1## wherein R.sup.1, R.sup.7, m, n, p, q, X, Y, Z, R and R.sup.15 are as defined in the specification.
Also disclosed are pharmaceutical compositions comprising the compounds of formula I.
Further disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines by administering compounds of formula I.
Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula I in combination or admixture with a histamine H.sub.1 receptor antagonist.

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Partial translation for WO 9629315.

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