Method and system for identifying and quantifying chemical...

Liquid purification or separation – With means to add treating material – Chromatography

Reexamination Certificate

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C210S656000, C250S282000, C702S019000, C702S022000, C702S030000

Reexamination Certificate

active

07056434

ABSTRACT:
Method and system for processing and evaluating data from combination chromatographic and mass spectrometric data. The methods and system comprise data smoothing and determination of an quality factor for a chromatogram of a data set based on a determined entropy value. In one embodiment, the methods and system further comprise data baseline correction prior to entropy value determination. In a further embodiment, a correlation is determined between chromatograms processed according to the invention and one or more chromatograms of one or more data sets. Preferably, said correlation is performed using a multivariate analysis.

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patent: 5672869 (1997-09-01), Windig et al.
patent: 5910655 (1999-06-01), Skilling
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patent: 6743364 (2004-06-01), van der Greef et al.
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patent: 2002/0053545 (2002-05-01), Greef
patent: 2002/0147550 (2002-10-01), Ito et al.
patent: WO 99/05591 (1999-02-01), None
patent: WO 99/05592 (1999-02-01), None
Windig, et al., “A Noise and Background Reduction Method for Component Detection in Liquid Chromatography/Mass Spectrometry,”Analytical Chemistry, vol. 68, No. 20 (Oct. 1996) pp. 3602-3606.
Zhang et al., “Enhancement of the Effective Resolution of Mass Spectra of High-Mass Biomolecules by Maximum Entropy-Based Deconvolution to Eliminate the Isotopic Natural Abundance Distribution,” Journal of American Society for Mass Spectrometry (1997) pp. 659-670.

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