Peptidyl prodrugs and linkers and stabilizers useful therefor

Details Peptidyl prodrugs and linkers and stabilizers useful therefor Peptidyl prodrugs and linkers and stabilizers useful therefor

2006-08-08

2006-08-08

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S411000, C544S142000, C548S429000

Reexamination Certificate

active

07087600

ABSTRACT:
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.

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