Method of preparing a guanosine-group compound and an...

Details Method of preparing a guanosine-group compound and an... Method of preparing a guanosine-group compound and an...

2006-11-28

2006-11-28

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S193000, C435S252500, C435S087000, C435S089000, C536S124000, C536S027100, C536S027300

Reexamination Certificate

active

07141397

ABSTRACT:
A glyoxal-guanosine-group compound is prepared either by reacting glyoxal-guanine with any one of ribose-1-phosphate and 2-deoxyribose-1-phosphate in the presence of purine nucleoside phosphorylase, or by reacting glyoxal-guanine with any one selected from the group consisting of uridine, 2′-deoxyuridine and thymidine, together with phosphate ion, in the presence of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase. The glyoxal-guanosine-group compound is then decomposed by alkali, whereby a guanosine-group compound consisting of guanosine and 2′-deoxyguanosine is prepared.

REFERENCES:
patent: 0 411 158 (1990-02-01), None
patent: 0 896 065 (1999-02-01), None
patent: 05170767 (1993-07-01), None
Chemical Abstracts Service, Columbus, Ohio, US, XP-002191262, abstract of Chung et al.,Carcinogenesis6(11), 1671-3 (1985).
Paladino et al.,J. Am. chem., Soc.,1986 108(19), 6066-6068.

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