Pyrazine derivatives useful as platelet aggregation inhibitors

Details Pyrazine derivatives useful as platelet aggregation inhibitors Pyrazine derivatives useful as platelet aggregation inhibitors

1988-03-14

1988-11-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544336, 544410, A61K 31495, C07D24112

Patent

active

047881976

ABSTRACT:
Novel pyrazine derivatives are disclosed. The compounds possess a potent platelet aggregation-inhibiting activity and are effective for preventing diseases caused by aggregation of the platelet, for example, myocardial infarction and cerebral thromobsis. Representative examples of the pyrazine derivatives includes 2,3-bis(p-chlorophenyl)-5-methylpyrazine, 2,3-bis(p-methoxyphenyl)-5-methylpyrazine, 2,3-diphenyl-5-benzylpyrazine, 2,3-diphenyl-5-(p-methoxybenzyl)pyrazine, 2,3-bis(p-methoxyphenyl)-5-isopropylpyrazine, 2,3-bis(p-methoxyphenyl)-5-(2-thienylmethyl)pyrazine and 2,3-bis(p-methoxyphenyl)-5,6-dimethylpyrazine.
The pyrazine derivatives can be generally prepared by heating a benzil derivative and a 1,2-diaminoethane derivative to produce a dihydropyrazine derivative and heating the resulting compound with sulfur at 100.degree.-180.degree. C.

REFERENCES:
patent: 4046763 (1977-09-01), Schwartz et al.
patent: 4064124 (1977-12-01), Weitz et al.
Beilsteins Handbook, of Organic Chemistry, 4th ed., vol. 23, p. 271 (1936).
Boyer, et al., Chem. Abstracts, vol. 78 (1973), Entry 124176s.
Chemical Abstracts, vol 83, No. 5, Aug. 4, 1975, Entry 43267y; Padwa, A., et al., "Synthesis of and Base-Induced Rearrangements in the 1,4-diazabicyclo[4.1.0]-Hept-4-Ene System", J. Org. Chem., (1975) 40(12), pp. 1683-1688.
Chemical Abstracts, vol. 96, No. 9, Mar. 1, 1982, Entry 68932t; Yamanaka, H., et al., "Studies on Pyrimidine Derivatives, XXIII, Synthesis of Acylmethylpyrimidines and Related Compounds via Imidoylsubstituted Oxosulfonium Ylides", Chem. Pharm. Bull., (1981) 29(10), pp. 2837-2843.
Chemical Abstracts, vol. 102, No. 1, Jan. 7, 1985, Entry 6421j; Ohta, A., et al., "Introduction of the Methyl Group Into the Pyrazine Ring", Heterocycles (1984), 22(10), pp. 2317-2321.
J. Heterocyclic Chem., 21, 103 (1984).
Chemical Abstracts, vol. 99, No. 11, Sep. 12, 1983, Entry 88170h; Joshi, S. C., et al., "A New Synthesis of Pyrazines", Indian J. Chem., Sect. B (1983) 22B(4), pp. 396-397.

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