Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors

Details Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors Alpha-aryl or heteroaryl-substituted amide ester ACAT inhibitors

1993-11-22

1995-05-30

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

544329, 544332, 560 37, 560 44, C07C22936, A61K 3124

Patent

active

054203392

ABSTRACT:
Pharmaceutically useful compounds having acylcoenzyme A: cholesterol acyltransferase inhibitory activity having the general formula ##STR1## wherein Ar is di- or trisubstituted aryl or heteroaryl; R.sub.14 and R.sub.15 are each independently aryl, heteroaryl, hydrogen, fluorine, or alkyl, with the proviso that R.sub.14 and R.sub.15 are not both hydrogen, fluorine, or a straight or branched chain alkyl or a combination thereof; and R.sub.16 is a straight or branched hydrocarbon chain having 1 to 20 carbon atoms and is saturated or unsaturated and has 1 to 3 double bonds, the double bonds being adjacent or nonadjacent.

REFERENCES:
patent: 5079137 (1992-01-01), Taguchi et al.
patent: 5123951 (1992-06-01), See et al.
patent: 5334747 (1994-08-01), Steffen et al.

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