Composition improved in the solubility or oral absorbability

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

Reexamination Certificate

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Reexamination Certificate

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07125565

ABSTRACT:
An object of the present invention is to provide a composition improved in the solubility or oral absorbability.The present invention provides a composition which comprises three components of a slightly water-soluble component, a surfactant and a hydrophilic polymer, and is obtainable by wet granulation in the presence of water.

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K Kakemi et al, “Mechanism of Drug Absorption from Micellar Solution”, Chem. Pharm. Bull., 18(8)1563-1568(1970), pp. 1563-1569.
S. Solvang et al., “Effect of Tablet Processing and Formulation Factors on Dissolution Rate of the Active Ingredient in Human Gastric Juice”, Journal of Pharmaceutical Sciences, vol. 59, No. 1, Jan. 1970, pp. 49-53.
J. Sxojtli, “Cyclodextrins in Drug Formulations: Part II”, Pharmaceutical Technology, Aug. 1991, pp. 24f.
P. Finholt, “Influence of Formulation on Dissolution Rate”, Dissolution Technology, The Industrial Pharmaceutical Technology Section of the Academy of Pharmaceutical Sciences.

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