Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-27
2006-06-27
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S411000, C540S456000
Reexamination Certificate
active
07067526
ABSTRACT:
Rapamycin derivatives containing substituents at C-28 in the epi orientation relative to rapamycin are disclosed, together with methods for their preparation and use, e.g. for regulation of biological phenomena in engineered cells. The compounds may contain optional additional modifications relative to rapamycin, as disclosed herein.
REFERENCES:
patent: 5091389 (1992-02-01), Ondeyka
patent: 5109112 (1992-04-01), Siekierka
patent: 5116756 (1992-05-01), Dumont
patent: 5140018 (1992-08-01), Klein
patent: 5147877 (1992-09-01), Goulet
patent: 5198421 (1993-03-01), Chen
patent: 5200411 (1993-04-01), Edmunds
patent: 5208241 (1993-05-01), Ok
patent: 5210030 (1993-05-01), Petuch
patent: 5221625 (1993-06-01), Chen
patent: 5225403 (1993-07-01), Treiber
patent: 5247076 (1993-09-01), Goulet
patent: 5252732 (1993-10-01), Sinclair
patent: 5258389 (1993-11-01), Goulet
patent: 5310901 (1994-05-01), Parsons
patent: 5310903 (1994-05-01), Goulet
patent: 5318895 (1994-06-01), Kahn
patent: 5324644 (1994-06-01), Ruby
patent: 5362735 (1994-11-01), Luengo
patent: 5373014 (1994-12-01), Failli
patent: 5378836 (1995-01-01), Kao
patent: 5387680 (1995-02-01), Nelson
patent: 5457182 (1995-10-01), Wiederrecht
patent: 5457194 (1995-10-01), Luly
patent: 5484799 (1996-01-01), Hochlowski
patent: 5525610 (1996-06-01), Caufield
patent: 5527907 (1996-06-01), Or
patent: 5534632 (1996-07-01), Or
patent: 5541189 (1996-07-01), Luly
patent: 5541193 (1996-07-01), Kawai
patent: 5561137 (1996-10-01), Or
patent: 5561228 (1996-10-01), Or
patent: 5563172 (1996-10-01), Wagner
patent: 5583139 (1996-12-01), Or
patent: 5597715 (1997-01-01), Ford
patent: 5604234 (1997-02-01), Or
patent: 5622866 (1997-04-01), Motamedi
patent: 5648361 (1997-07-01), Holt
patent: 5985890 (1999-11-01), Cottens
patent: 5985906 (1999-11-01), Meingassner
patent: 6013627 (2000-01-01), Dreyfuss
patent: 6066721 (2000-05-01), Khosla
patent: 6150137 (2000-11-01), Berlin
patent: 6187757 (2001-02-01), Clackson
patent: 0614871 (1994-09-01), None
patent: WO91/13889 (1991-09-01), None
patent: WO92/05179 (1992-04-01), None
patent: WO92/14737 (1992-09-01), None
patent: WO92/19595 (1992-11-01), None
patent: WO93/04680 (1993-03-01), None
patent: WO93/10122 (1993-05-01), None
patent: WO93/11130 (1993-06-01), None
patent: WO93/13663 (1993-07-01), None
patent: WO93/18043 (1993-09-01), None
patent: WO93/25533 (1993-12-01), None
patent: WO94/02136 (1994-02-01), None
patent: WO94/02137 (1994-02-01), None
patent: WO94/04540 (1994-03-01), None
patent: WO94/09010 (1994-04-01), None
patent: WO94/10843 (1994-05-01), None
patent: WO94/18207 (1994-08-01), None
patent: WO94/21644 (1994-09-01), None
patent: WO94/25022 (1994-11-01), None
patent: WO95/04060 (1995-02-01), None
patent: WO95/04738 (1995-02-01), None
patent: WO95/07468 (1995-03-01), None
patent: WO95/15328 (1995-06-01), None
patent: WO95/16691 (1995-06-01), None
patent: WO 96/41865 (1996-12-01), None
patent: WO97/10502 (1997-03-01), None
patent: WO98/02441 (1998-01-01), None
patent: WO 98/09972 (1998-03-01), None
patent: WO 99/36553 (1999-07-01), None
Hayward et al., “Total synthesis of Rapamycin via a novel Titanium-mediated aldol macrocyclisation reaction.” —(1993) Journal of the American Chemical Society, 115: 9345-9346.
Mahrwald et al., “Synthesis of A, B-unsaturated carbonyl compounds by titanium tetraalkoxide-inducing aldol condensation under neutral conditions.” —(1990) Synthesis, De Georg Thieme Verlag. Stuttgart, No. 7, 592-595.
Swiss, K. A., “Use of Magnesium cation in aldol additions. A convenient method for achieving anti-aldol selectivity.” —(1991) Journal of Organic Chemistry, 56:5978-5980.
Yang et al., “Selective epimerization of Rapamycin via a retroaldol/alodl mechanism mediated by Titanium tetraisopropoxide.” —(1999) Organic Letters, 1:2033-2035.
Borrelli, et al., (1988) Proc. Natl. Acad. Sci. USA, vol. 85:7572-7576.
Breitman, et al., (1987) Science, vol. 238: 1563-1565.
Breitman et al., (1990) Mol. Cell. Biol., vol. 10: 474-479.
Brown, et al., (1994) Nature, vol. 369: 756-758.
Chen, et al., (1995) PNAS USA, vol. 92: 4947-4951.
Chiu et al., (1994) PNAS USA, vol. 91: 12574-12578.
Cunningham et al., (1989) Science, vol. 244: 1081-1085.
Das et al., (1995) Nature, vol. 374: 657-660.
Dennis et al, (1994) J. Biol. Chem, vol. 269: 22129-22136.
Ferry et al., (1991) PNAS USA, vol. 88: 8377-8381.
Fields et al., (1989) Nature, vol. 340: 245-246.
Flotte et al., (1993) J. Biol. Chem, vol. 268: 3781-3790.
Graef et al., (1997) EMBO J. 16: 5618-5628.
Grinfeld, et al., (1994) Tetrahedron Letters, vol. 35: 6835-6838.
Helliwell et al., (1994) Mol Biol Cell 5: 105-118.
Heyman et al., (1989) PNAS USA, vol. 86: 2698-2702.
Hiebert et al., (1989) Proc. Natl. Acad. Sci, USA, vol. 86: 3594-3598.
Ho, et al., (1996) Nature, vol. 382: 822-826.
Holsinger, et al., (1995) PNAS USA, vol. 92: 9810-9814.
Hu, (1995) Science, vol. 3: 431-433.
Hu et al., (1990) Science, vol. 250: 1400-1403.
Kaneda et al., (1989) Science, vol. 243: 375-378.
Kay, (1996) Biochem. J., vol. 314: 361-385.
Kordower et al., (1994) PNAS USA, vol. 91(23): 10898-902.
Kunz et al., (1993) Cell, vol. 73: 585-596.
Lakey et al., (1995) Transplantation Proc., vol. 27(6): 3266.
Liberles et al, (1997) PNAS USA, vol. 94: 7825-7830.
Luengo et al., (1995) J. Org. Chem., 59, 6512.
Luengo et al., (1995) Current Biology, 2: 471-481.
Luengo et al., (1995) Chem & Biol, vol. 2(7): 471-481.
Luo, et al., (1996) Nature, vol. 383: 181-185.
Muller et al., (1991) MCB, vol. 11: 1785-1792.
Palmiter, et al., (1987) Cell, vol. 50: 435-443.
Pomeranz, et al., (1995) Science, vol. 267: 93-96.
Belshaw, et al., (1996) PNAS USA, vol. 93: 4604-4607.
Grinfeld, et al., (1994) Tetrahedron Letters, vol. 35: 6835-6838.
Kay, J. E., (1996) Biochem. J., vol. 314: 361-385.
Luengo et al., (1993) Tetrahedron Lett., vol. 34: 991-994.
Luengo et al., (1994) Tetrahedron Lett., vol. 35: 6469-6472.
Luengo et al., (1995) J. Org. Chem., vol. 59, 6512.
Luengo et al., (1995) Current Biology, vol. 2: 471-481.
Smith et al., (1997) J. Am. Chem. Soc., vol. 119: 962-973.
Uchiyama, et al., (1993) Peptide Chemistry, vol. 31: 89-92.
Van Duyne et al., (1991) J. Amer. Chem. Soc., vol. 113: 7433-7434.
Digits Cheryl A.
Holt Dennis A.
Rozamus Leonard
Yang Wu
Ariad Gene Therapeutics, Inc.
Berstein, Esq. David L.
Choate,Hall & Stewart LLP
Jarrell, Esq. Brenda Herschbach
Kifle Bruck
LandOfFree
28-epirapalogs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 28-epirapalogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 28-epirapalogs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3634104