Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-09-28
1998-08-25
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 21, A61K 3818, C07K 14475, C07K 14495
Patent
active
057983348
ABSTRACT:
The invention relates to a pharmaceutical composition for normalizing the fibrogenic effect of an agonist which comprises an effective amount of an agonist to stimulate normal collagen synthesis together with an effective amount of an antagonist to reduce the agonist-mediated increase of collagen synthesis and collagen gene expression, together with a pharmaceutically acceptable carrier. The invention also relates to a method of normalizing the fibrogenic effect of an agonist with said composition.
REFERENCES:
Meisler, et al., "Dexamethasone Abrogates the Fibrogenic Effect of Transforming Growth Factor-(beta) in Rat Granuloma and Granulation Tissue Fibroblasts," The Society for Investigative Dermatology, Inc., 108:285-289 (1977).
Ritzenthaler et al., Regulation of the .alpha.1 (I) collagen promoter via a transforming growth factor-.beta. activation element. J. Biol. Chem. 268:12625-16631 (1993).
Jimenez et al., Functional analysis of human .alpha.1 (I) procollagen gene promoter, J. Biol. Chem. 269:12684-12691 (1998).
Rossi et al, A nuclear factor 1 binding site mediates the transcriptional activation of a type 1 collagen promoter by transforming growth factor .beta., Cell 52:405-414 (1988).
Inagaki et al., Transforming growth factor .beta. stimulates .alpha.2 (I) collagen gene expression through a cis-acting lement that contains an Sp1-binding site, J. Biol. Chem. 269:14828-14834 (1994).
Ritzenthaler et al., Transforming-growth-factor-.beta. activation elements in the distal promoter regions of the rat .alpha.1 type I collagen gene, Biochem. J. 280:157-162 (1991).
Newman et al., Glucocorticoids selectively decrease the synthesis of hydroxylated collagen peptides, Mol. Pharmacol. 14:185-198 (1978).
Lichtler et al., Isolation and characterization of the rat .alpha.(1) collagen promoter, J. Biol. Chem 264:3072-3077 (1989).
"Current Protocols in Molecular Biology" (vol. 1, p. 1.7.6).
Chen et al., High-efficiency transformation of mammalian cells by plasmid DNA, Mol. Cell Biol. 7:2745-2752 (1987).
Gorman et al., Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell Biol. 2:1044-1051 (1982).
Southern et al., Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter, J. Mol. Appl. Genet. 1:327-341 (1982).
Neumann et al., A novel rapid way for chloramphenicol acetyltransferase gene expression, BioTechiniques, 5:444-447 (1987).
Lowry et al., Protein measurement with the folin phenol reagent, J. Biol. Chem. 193:265-275 (1951).
Andrews et al., A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells, Nucleic Acid Res. 19:2499 (1991).
Cutroneo et al., anti-inflammatory steroids and collagen metabolism: Glucocorticoid-mediated alterations of prolyl hydroxylase activity and collagen synthesis, Mol. Pharmacol. 11:632-639 (1975).
Martens et al., Gut, 33(12) pp. 1664-1670 (1992). Abstract.
Amento and Beck, Ciba Foundation Symposium, (157) discussion 123-9, pp. 115-123 (1991). Abstract.
Beck et al., J. Clin. Invest. 92(6) 2841-9 (1993).
"Dexamethasone Abrogates the Fibrogenic Effect of Transforming Growth Factor-.beta. in Rat Granuloma and Granulation Tissue Fibroblasts," N. Meisler et al., in J. Invest. Dermatol., 108:285-289, 1997.
Colla-Gene, Inc.
Touzeau P. Lynn
Tsang Cecilia J.
LandOfFree
Pharmaceutical compositions for scarless tissue repair and regen does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions for scarless tissue repair and regen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions for scarless tissue repair and regen will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-36339