Leukemia inhibitory factor receptors and fusion proteins

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530402, 5303873, 5303911, 53038823, 536 2351, C07K 1300

Patent

active

054202477

ABSTRACT:
Leukemia inhibitory factor receptor (LIF-R) proteins, DNAs and expression vectors encoding LIF-R, and processes for producing LIF-R as products of recombinant cell culture, are disclosed.

REFERENCES:
patent: 4518584 (1985-05-01), Mark et al.
patent: 4675285 (1987-06-01), Clark et al.
patent: 5071972 (1991-12-01), Larsen
patent: 5155027 (1992-10-01), Sledziewski et al.
Allan et al., "Osteoblasts display receptors for and responses to leukemia-inhibitory factor", J. Cell Physiol. 145:110-119; 1990.
Williams et al., "Myelokd leukemia inhibitory factor maintains the development potential of embryonic stem cells", Nature 336:684-687; 1988.
Tomida et al., "Inhibition of development of NA.sup.+ dependent hexose transport in renal epithelial LLC-PK1 cells . . . for myeloid leukemic cells/leukemia inhibitory factor", FEBS 268:261-264; 1990.
Gearing et al., "Expression cloning of a receptor for human granulocyte-macrophage colonystimulating factor", EMBO J. 8:3667-3676; 1989.
Yamasaki et al., "Cloning and Expression of the Human Interleukin-6 Receptor", Science 241:825-828; 1988.
Cosman, "Expression Cloning of Cytokines and Cytokine Receptors by Screening Pools of cDNA Clones", DNA & Prot. Eng. Tech. 2:1-28, 1990.
Gearing et al., "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer", gp130, EMBO J. 10:2839; 1991.
Sims et al., "cDNA Expression Cloning of the IL-1 Receptor: a Member of the Immunoglobulin Superfamily", Science 241:585-589; 1988.
Belyavsky et al., "PCR-based cDNA Library Construction; General cDNA Libraries at the Level of a Few Cells", Nucl. Acids Res. 17: Aug. 1989.
Smith et al., "Blocking of H1V-I Infectivity by a Soluble, Secreted Form of the CD4 Antigen", Science 238:1704-1707; 1987.
Baumann and Wong, "Hepatocyte-Stimulating Factor III Shares Structural and Functional Identity with Leukemia Inhibitory Factor", J. Immunol. 143:1163; 1989.
Yamamori et al., "The Clolinergic Neuronal Differentiation Factor from Heart Cells is Identical to Leukemia Inhibitory Factor", Science 246:1412; 1990.
Mori et al., "Purification of a Lipoprotein Lipase-Inhibiting Protein Produced by a Melanoma Cell Line Associatd with Cancer Cachexia" Biochem. Biophys. Res. Comm. 160:1085; 1989.
Moreau et al., "Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells", Nature 336:690; 1988.
Abe et al., "Macrophage Differentiation Inducing Factor from Human Monocytic Cells is Equivalent to Murine Leukemia Inhibitor Factor", J. Biol. Chem. 264:8941; 1989.
Smith and Hooper, "Buffalo Rat Liver Cells Produce a Diffusible Activity Which Inhibits the Differentiation of Murine Embryonal Carcinoma and Embryonic Stem Cells", Devel. Biol. 121:1; 1987.
Koopman and Cotton, "A Factor Produced by Feeder Cells which Inhibits Embryonal Carcinoma Cell Differentiation", Exp. Cell. Res. 154:233; 1984.
Tomida et al., "Purification of a Factor Inducing Differentiation of Mouse Myeloid Leukemic M1 Cells from Conditioned Medium of Mouse Fibroblast L929 Cells" J. Biol. Chem. 259:10978; 1984.
Hilton et al., "Resolution and Purification of Three Distinct Factors produced by Krebs Ascites Cells Which Have Differentiation-inducing Activity on Murine Myeloid Lekemic Cells Lines", J. Biol. Chem. 263:9238; 1988.
Gough et al., "Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor", Proc. Natl. Acad. Sci. USA 85:2623; 1988.
Metcalf et al., "Effects of Injected Leukemia Inhibitory Factor on Hematopoietic and Other Tissues on Mice", Blood 76:50; 1990.
Hilton et al., "Specific Binding of Murine Leukemia Inhibitory Factor to Normal and Leukemic Monocytic Cells", Proc. Natl. Acad. Sci. USA 85:5971; 1988.
Jacques et al., "High-Affinity Receptors for Human HILDA/LIF on Human Cell Lines", 5th Symposium sur les Marquers de l'Inflammation, (Lyon 25-27 Sep. 1990).
Hilton et al., "Distribution of LIF receptors during embryogenesis", Article 45, Annual Review, The Walter and Eliza Hall Institute of Medical Research; 1990.
Brown et al., "Analysis of leukaemia inhibitory factor expression", Article 55, Annual Review, The Walter and Eliza Hall Institute of Medical Research; Jun. 1989-Jul. 1990.
Stewart et al., "Blastocyte implantation depends on maternal expression of leukaemia inhibitory factor", Nature 359:76-79; 1992.
Heath, "Can there be life without LIF?", Nature 359:17; 1992.
Hilton et al., "Distribution and Comparison of Receptors for Leukemia Inhibitory Factor on Murine Hematopoietic and Hepatic Cells", J. Cell. Phys. 146:207-215; 1991.
Gearing and Bruce, "Oncostatin M Binds the High-Affinity Leukemia Inhibitory Factor Receptor", The New Biologist 4:61-65; 1992.
Gearing, "Leukemia Inhibitory Factor: Does the Cap Fit?", Ann. of the N.Y. Acad. Sci. 628:9-18; 1991.
Gearing et al., "The IL-6 Signal Transducer, gp130: An Oncostatin M Receptor and Affinity Converter for the LIF Receptor ", Science 255:1434-1437; 1992.
Aruffo and Seed, "Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system", Proc. Natl. Acad. Sci. USA 84:8573-8577; 1987.
Lesslauer et al., "Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality", Eur. J. Immunol. 21:2883-2886; 1991.
Peppel and Beutler, "Chimaeric TNF-Receptor-IgG Molecule Acts as Soluble Inhibitor of TNF Mediated Cytotoxicity", J. Cell. Biochem. (Abstr), Suppl. 15F; Apr. 1991.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Leukemia inhibitory factor receptors and fusion proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Leukemia inhibitory factor receptors and fusion proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leukemia inhibitory factor receptors and fusion proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-362879

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.