Gene expression with covalently modified polynucleotides

Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification

Reexamination Certificate

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C435S455000, C435S468000, C514S04400A

Reexamination Certificate

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07049142

ABSTRACT:
A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can be used to facilitate the change of tertiary structure of the nucleic acid and in some cases condensation of nucleic acids into smaller, charged particles useful in delivering the nucleic acid to a cell.

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