RNA binding protein and binding site useful for expression...

Details RNA binding protein and binding site useful for expression... RNA binding protein and binding site useful for expression...

2006-10-17

2006-10-17

Ketter, James (Department: 1636)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S320100, C435S419000, C435S069100, C435S375000, C435S468000, C536S023100

Reissue Patent

active

RE039350

ABSTRACT:
The present invention relates to a gene expression system in eukaryotic and prokaryotic cells, preferably plant cells and intact plants. In particular, the invention relates to an expression system having a RB47 binding site upstream of a translation initiation site for regulation of translation mediated by binding of RB47 protein, a member of the poly(A) binding protein family. Regulation is further effected by RB60, a protein disulfide isomerase. The expression system is capable of functioning in the nuclear/cytoplasm of cells and in the chloroplast of plants. Translation regulation of a desired molecule is enhanced approximately 100 fold over that obtained without RB47 binding site activation.

REFERENCES:
patent: 5693507 (1997-12-01), Daniell et al.
During et al., Plant Molecular Biology, vol. 15 (1990), pp. 281-293.
Danon et al., EMBO J., vol. 10, 1991, pp. 3993-4001.
Danon et al., EMBO J., vol. 13, 1994, pp. 2227-2235.

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