Piperidine derivatives for treating allergy

Details Piperidine derivatives for treating allergy Piperidine derivatives for treating allergy

1994-02-22

1995-05-30

Chang, Celia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546196, C07D40512, A61K 31445

Patent

active

054201438

ABSTRACT:
A piperadine derivative of formula (1): ##STR1## a salt thereof and a drug containing the derivative as an effective component.
This compound has excellent antihistamine activity and antileukotriene activity, which are well balanced, and thus they are useful for the prevention and treatment of asthma or other allergic diseases such as allergic rhinitis, allergic dermatosis and urticaria.

REFERENCES:
patent: 4950674 (1990-08-01), Yanni et al.
patent: 5250681 (1993-10-01), Shoji
patent: 5286735 (1994-02-01), Bonnaud
Journal of Medicinal Chemistry, vol. 32, No. 1, Jan. 1989, David A. Walsh, et al., "Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-[3-(Aryloxy)Proptyl]Piperidines and Structurally Related Compounds", pp. 105-118.

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