Aporphine and oxoaporphine compounds and pharmaceutical use...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S284000

Reexamination Certificate

active

07057044

ABSTRACT:
The invention provides aporphine and oxoaporphine compounds that have endothelial nitric oxide synthase (eNOS) maintaining or enhancing activities and may be used to manufacture a medicaments for preventing or treating ischemic diseases in human and mammal, and the ischemic diseases may include ischemic cerebral apoplexy, ischemic cerebral thrombosis, ischemic cerebral embolism, hypoxic ischemic encephlopathy, ischemic cardiac disease or ischemic enteropathy etc.

REFERENCES:
patent: 5156847 (1992-10-01), Lewis et al.
Khroyan, TV et al ‘Dopamine D1- and D2- like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selecti antagonists and agonists’ J. of Pharmacology and Experimental Therapeutics (2000), 294(2), 680-687.
Lan, YH et al ‘Cytotoxic styrylpyrones fromGoniothalamus amuyon’ J. of Natural Products (2003), 66(4), 487-490.
Zhang, CF et al ‘Sesquiterpenes and alkaloids fromLindera chuniiand their inhibitory activities against HIV-1 integrase’ Chemical & Pharmaceutical Bulletin, (2002), 50(9), 1195-1200.
Li-Man Hung, et al. “Thaliporphine Protects Ischemic and Ischemic-Reperfused Rat Hearts Via an NO-Dependent Mechanism” Drug Development Research 52:446-453 (2001).

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