Processes for purifying and for detecting target...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C536S023100

Reexamination Certificate

active

07052838

ABSTRACT:
The present invention relates to novel target double-stranded DNA sequences capable of interacting with a third strand and of forming a stable triple helix. The present invention also relates to a process for purifying a double-stranded DNA molecule, according to which a solution containing said DNA molecule is brought into contact with a third DNA strand capable of forming, by hybridization, a triple helix structure with a target double-stranded DNA sequence carried by said DNA molecule.

REFERENCES:
patent: 6265166 (2001-07-01), Frank-Kamenetskii et al.
patent: 6287762 (2001-09-01), Crouzet et al.
patent: 6319672 (2001-11-01), Crouzet et al.
patent: WO 96/18744 (1996-06-01), None
patent: WO 00/46366 (2000-08-01), None
Bukanov et al (Proc. Natl. Acad. Sci. (1998) 95:5516-5520).
Takabatake et al (Nucleic Acids Research (1992) 20(21):5853-5854).
Fossella, J.A., et al., “Relative Specificities in Binding of Watson—Crick Base Pairs by Third Strand Residues in a DNA Pyrimidine Triplex Motif,”Nucleic Acids Research, 21:4511-4515 (1993).
Gowers, D.M. and Fox, K.R., “Triple Helix Formation at (AT)nAdjacent to an Oligopurine Tract,”Nucleic Acids Research, 26:3626-3633 (1998).
Gowers, D.M., et al., “DNA Triple Helix Formation at Oligopurine Sites Containing Multiple Contiguous Pyrimidines,”Nucleic Acids Research, 25:3787-3794 (1997).
Kiessling L.L., et al. “Flanking Sequence Effects Within the Pyrimidine Triple-Helix Motif Characterized by Affinity Cleaving,”Biochemistry, 31:2829-2834 (1992).
Radhakrishnan, I., et al. “DNA Triplexes: Solution Structures, Hydration Sites, Energetics, Interactions, and Function,”Biochemistry, 33:11405-11416 (1994).
Soyfer, V.N. and Potaman, V.N., eds., “Triple-Helical Nucleic Acids,”Chapter 4: Triplex Recognition pp. 151-169, Springer, (1995).
Yoon, K., et al., “Elucidation of the Sequence-Specific Third-Strand Recognition of Four Watson—Crick Base Pairs in a Pyrimidine Triple-Helix Motif: T-AT, C-GC, T-CG, and G-TA,”Proc. Natl. Acad. Sci. USA., 89:3840-3844 (1992).

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