Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-06-13
2006-06-13
Weber, Jon (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C530S417000
Reexamination Certificate
active
07060460
ABSTRACT:
In a method for reconstituting a recombinant protein from a denatured state to its active form, a feed solution containing the recombinant protein in its denatured and/or in biologically inactive intermediate forms is subjected to a chromatographic separation process, in which the protein is reconstituted under conditions that promote refolding of the protein and the intermediate forms are separated from the refolded protein. The denatured form and/or the inactive intermediate forms of the protein are separated from the refolded protein in a continuous or quasi-continuous manner and optionally recycled to the feed solution.
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Martin, A.J.P., “S
Jungbauer Alois
Machold Christine
Necina Roman
Schlegl Robert
Boehringer Ingelheim Austria GmbH
Mondesi Robert B.
Sterne Kessler Goldstein & Fox P.L.L.C.
Weber Jon
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