Process for forming multilayer bioreplaceable blood vessel prost

Details Process for forming multilayer bioreplaceable blood vessel prost Process for forming multilayer bioreplaceable blood vessel prost

1987-01-12

1988-11-29

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

264 86, 264 41, A61F 206, B28B 126, B01D 1304

Patent

active

047879009

ABSTRACT:
Process for forming a multilayer blood vessel prosthesis. Each layer is formed from bioreplaceable materials which include those produced by contacting collagen with an aminopolysaccharide and subsequently covalently crosslinking the resulting polymer, polymers of hydroxyacetic acid and the like. Cross flow filtration molding and wet extrusion molding are two processes which are particularly useful for forming the inner layer of the blood vessel prosthesis. The outer layer of the blood vessel prosthesis is preferably formed by freeze drying a dispersion of the bioreplaceable material onto the inner layer(s). The disclosed blood vessel prosthesis is a multilayer structure with each layer having a porosity and other physicochemical and mechanical characteristics selected to maximize the effectiveness of the blood vessel. The prosthesis functions initially as a thromboresistant conduit with mechanical properties which match those of the adjacent natural blood vessel. Eventually, the prosthesis functions as a regeneration template which is replaced by new connective tissue that forms during the healing process following attachment of the prosthesis.

REFERENCES:
patent: 4060081 (1977-11-01), Yannas et al.
patent: 4252759 (1981-02-01), Yannas et al.
patent: 4355426 (1982-10-01), MacGregor
patent: 4418691 (1983-12-01), Yannas et al.
Yannas et al, "Design of an Artificial Skin, Part III, Control of Pore Structure", J. Biomed. Res., vol. V14, 511-528 (1980).

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