Synthesis of 5-azacytidine

Details Synthesis of 5-azacytidine Synthesis of 5-azacytidine

2006-05-02

2006-05-02

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S124000, C536S028500, C536S028100, C536S023100, C536S024310, C536S024330, C536S022100, C514S049000, C514S085000, C514S269000, C424S045000, C424S450000

Reexamination Certificate

active

07038038

ABSTRACT:
The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure:The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected β-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).

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