Human ice homolog

Details Human ice homolog Human ice homolog

1995-08-01

2000-03-07

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 435183, 4353201, 536 231, 536 232, 536 241, C12Q 168, C07H 2104, C12N 900, C12P 2102

Patent

active

060338482

ABSTRACT:
The present invention provides a polynucleotide (icel) which identifies and encodes a human ice homolog (ICEL) expressed in lung cells and tissues. The present invention also provides for antisense molecules and oligomers designed from the nucleotide sequence or its antisense. The invention further provides genetically engineered expression vectors and host cells for the production of purified ICEL peptide, antibodies capable of binding to ICEL, inhibitors which bind to ICEL and pharmaceutical compositions based on ICEL specific antibodies or inhibitors. The invention specifically provides for diagnostic assays which identify a disorder or disease with altered icel expression which allows identification and monitoring of hospital patients. These assays utilize icel encoding or controlling nucleic acid sequences, fragments or oligomers thereof, or antibodies specific for the peptide.

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patent: 5856169 (1999-01-01), Litwack et al.
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Munday et al. Molecular Cloning and Pro-Apoptotic Activity of ICEreIII and ICEreIIII, Members of the ICE/CED-3 Family of Cysteine Proteases. J. Biol. Chem. 270 (26: 15870-15876, Jun. 30, 1995.
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