Urea derivatives and their use as ACAT inhibitors

Details Urea derivatives and their use as ACAT inhibitors Urea derivatives and their use as ACAT inhibitors

1994-05-18

1997-04-15

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514597, 514598, 514824, 546146, 546332, 5462754, 5462727, 548178, 5482628, 5483561, 564 48, 564 50, 564 52, 564 53, 564 54, 544360, 544371, 544372, A61K 3117, C07C27300, C07D24908, C07D21712

Patent

active

056210108

ABSTRACT:
Urea derivatives of formula (I) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

REFERENCES:
patent: 5290814 (1994-03-01), Jackson et al.
patent: 5422373 (1995-06-01), Franzmann
Arterioschlerosis 4, 357-364 (1984), Morel, D.W., et al.
Proc. Natl. Acad. Sci., 84, 5928-5931 (1987) Kita, T., et al.
J. Lipid Resch. 30, 681-690 (1989), Largis, E.E., et al.
Japan J. Pharm., 42, 5127-523 (1986) Natori, K., et al.
J. Med. Chem., 34, 298-302 (1991), Mao, S.J.T., et al.

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