Isoxazole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S380000, C548S240000, C548S243000

Reexamination Certificate

active

07022725

ABSTRACT:
A compound represented by the formula (I)wherein one of R1and R2is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR3(wherein R3is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.

REFERENCES:
patent: 3752818 (1973-08-01), Plumpe et al.
patent: 5814627 (1998-09-01), Schwab et al.
patent: 6060494 (2000-05-01), Faasch et al.
patent: 0208040 (1987-01-01), None
patent: 0903345 (1999-03-01), None
patent: 69029656 (1969-02-01), None
patent: 54044665 (1979-04-01), None
patent: WP 98/28282 (1998-07-01), None
patent: WO 00/08001 (2000-02-01), None
patent: WO 00/38666 (2000-07-01), None
Fossa. et al. “5-Substituted 4-Isoxazoleacetic Acids with Analgesic Activity” IL FARMACO 49(1):41-44 (1994).

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