Transgenic mouse EDG2 knockout model

Details Transgenic mouse EDG2 knockout model Transgenic mouse EDG2 knockout model

2006-05-02

2006-05-02

Priebe, Scott D. (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal in an in vivo...

C800S018000

Reexamination Certificate

active

07038105

ABSTRACT:
The present invention provides a transgenic non-human animal and method for using the same in evaluating a therapeutic agent for use in the treatment of Schizophrenia. More specifically, the invention is directed to a transgenic non-human animal which is incapable of expressing functional EDG2 protein. A theraupeutic agent is administered to the transgenic non-human animal incapable of expressing functional EDG2 protein and the effect of the agent on the animal is evaluated.

REFERENCES:
patent: 2002/0061558 (2002-05-01), Elshourbagy et al.
patent: 2002/0090691 (2002-07-01), Elshourbagy et al.
patent: 2199455 (1998-09-01), None
Prelle, K. 1999, Establishment of pluripotent cell lines from vertebrate species-present status and future prosopects, Cells Tissues Organs, vol. 165, pp. 220-236.
Campbell and Wilmut, 1997, Totipotency or multipotency of cultured cells: applications and progress, Theriogenology, vol. 47, pp. 63-72.
Wheeler, M.B. 2001, Transgenic technology and applications in swine. Theriogenology, vol. 56, pp. 1345-1369.
Contos et al., “Requirement for the 1pA1 lysophosphatidic acid receptor gene in normal suckling behavior,”Proc. Nat'l. Acad. Sci. USA97(24):13384-13389 (Nov. 2000).
Dulawa et al., “Serotonin-1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin-1B knockout mice,”Psychopharmacology132(2):125-134 (1997).
Muller, “Ten years of gene targeting: Targeted mouse mutants, from vector design to phenotype analysis,”Mechanisms of Development, Elsevier Science Ireland82(1-2):3-21 (Apr. 1999).
Bickerdike et al., “Social isolation attenuates rat forebrain 5-HT release induced by KCI stimulation and exposure to a novel environment,”Behavioural Pharmacology4:231-236 (1993).
Braff et al., “Sensorimotor gating and schizophrenia,”Arch. Gen. Psychiatry47(2):181-188 (1990).
Choi et al., “Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome,”Nature Genet. 4:117-123 (1993).
Cilia et al., “Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats,”Psychopharmacology156:327-337 (2001).
Costantini et al., “Introduction of a rabbit β-globin gene into the mouse germ line,”Nature294:92(Nov. 1981).
Durson et al., “Effects of clozapine and typical antipsychotic drugs on plasma 5-HT turnover and impulsivity in patients with schizophrenia: a cross-sectional study,”Journal of Psychiatry and Neuroscience25(4):347:352 (2000).
Fletcher et al., “Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex: effects of 5,7-dihydroxytrptamine and p-chlorophenylalanine,”Neuropsychopharmacology24(4):399-409 (Apr. 2001).
Fukushima et al., “The LPA receptors,”Prostaglandins&Other Lipid Mediators64:21-32 (2001).
Hervieu et al., “Gene expression and protein distribution of the Orexin-1 receptor in the rat brain and spinal cord,”Neuroscience103(3):777-797 (2001).
Kehne et al., “5-HT modulation of auditory and visual sensorimotor gating: I. Effects of 5-HT releasers on sound and light prepulse inhibition in Wistar rats,”Psychopharmacology124:95-106 (1996).
Mauvais-Jarvis et al., “Understanding the pathogenesis and treatment of insulin resistance and type 2 diabetes mellitus: what can we learn from transgenic and knockout mice,”Diabetes and Metabolism26:433-448 (2000).
Robbins et al., “Behavioural and neurochemical effects of early social deprivation in the rat,”J. Psychopharmacology10(1):39-47 (1996).
Strauss et al., “Germ line transmission of a yeast artificial chromosome spanning the Murine α1(1) collagen locus,”Science259:1904-1907 (Mar. 1993).
Wilkinson et al., “Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition,”Neuropsychopharmacology10(1):61-72 (1994).
Wright et al., “Effect of isolation-rearing on 5-HT release in the rat frontal cortex,”J. Neuroscience Methods29:283 (1989).

Affiliated with

Also associated with

Rating

Transgenic mouse EDG2 knockout model does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Transgenic mouse EDG2 knockout model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transgenic mouse EDG2 knockout model will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3606379