Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-07-04
2006-07-04
Murphy, Joseph J. (Department: 1647)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S069100, C435S320100, C435S325000, C435S375000, C435S377000, C530S399000, C536S023510
Reexamination Certificate
active
07070946
ABSTRACT:
The present invention is directed to a novel method of detecting a function or activity of a polypeptide which is related to bone metabolism, in particular, differentiation (maturation) of osteoblast or morphological change (retraction), specifically relating to a polypeptide which comprises an amino acid sequence shown by SEQ ID NO: 2 or SEQ ID NO: 4, an amino acid sequence in which one or several amino acids are deleted, substituted or added in the amino acid sequence shown by SEQ ID NO: 2 or SEQ ID NO: 4, or a polypeptide encoded by a nucleic acid which is capable of hybridizing under stringent condition with a nucleic acid comprising a nucleotide sequence shown by SEQ ID NO: 1 or SEQ ID NO: 3, or a complement sequence thereof.
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Karp, What we do not know about sequence analysis and sequence databases. Bioinformatics 14:753-754 (1998).
Akatsuka Hiroyuki
Imai Yuji
Kawai Eri
Omori Kenji
Sakurai Naoki
Birch & Stewart Kolasch & Birch, LLP
DeBerry Regina M.
Murphy Joseph J.
Tanabe Seiyaku Co. Ltd.
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