Method for the manufacture of a controlled release solid unit do

Details Method for the manufacture of a controlled release solid unit do Method for the manufacture of a controlled release solid unit do

1993-12-10

1995-05-30

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424489, 424480, 424494, 424484, A61K 916

Patent

active

054199182

ABSTRACT:
A method for the manufacture of oral controlled release dosage units containing hydroxypropyl methylcellulose wherein the aqueous granulation is performed in the presence of one or more solutes, which inhibit gel formation during the granulation but allows the formation of a gel when administered orally. Also the new dosage units prepared according to the invention are included.

REFERENCES:
patent: 4369172 (1983-01-01), Schor
patent: 4478819 (1984-10-01), Hercelin et al.
patent: 4559384 (1985-12-01), Normura et al.
patent: 4795327 (1989-01-01), Gaylord et al.
patent: 4871548 (1989-10-01), Edgren
patent: 4971805 (1990-11-01), Kitanishi et al.
patent: 5024842 (1991-06-01), Edgren
patent: 5071646 (1991-12-01), Malkowska et al.
Dow 1987, "Formulating Release with Methocel cellulose ethers", ppp. 1-32.

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