Radiant energy – With charged particle beam deflection or focussing – Magnetic lens
Reexamination Certificate
2006-01-31
2006-01-31
Lee, John R. (Department: 2881)
Radiant energy
With charged particle beam deflection or focussing
Magnetic lens
C250S42300F, C250S281000, C250S282000, C250S283000, C250S288000
Reexamination Certificate
active
06992299
ABSTRACT:
A method and apparatus for focusing ions for delivery to an ion detection device using an aerodynamic ion focusing system that uses a high-velocity converging gas flow at an entrance aperture to focus an ion plume by reducing spreading and increasing desolvation of ions, and wherein a voltage is applied to at least a portion of the aerodynamic ion focusing system to assist in the focusing and delivery of ions to the ion detection device.
REFERENCES:
patent: 4121099 (1978-10-01), French et al.
patent: 4861988 (1989-08-01), Henion et al.
patent: 5115131 (1992-05-01), Jorgenson et al.
patent: 5352892 (1994-10-01), Mordehai et al.
patent: 5412208 (1995-05-01), Covey et al.
patent: 5432343 (1995-07-01), Gulcicek et al.
patent: 5747799 (1998-05-01), Franzen
patent: 5838002 (1998-11-01), Sheehan
patent: 6278111 (2001-08-01), Sheehan et al.
patent: 6396064 (2002-05-01), Danilatos
patent: WO9534089 (1995-12-01), None
“A New Technique for Decomposition of Selected Ions in Molecule Ion Reactor Coupled With Ortho-Time-of-Flight Mass Spectrometry”, article written by A. Dodonov et al. forRapid Communications in Mass Spectrometry, vol. II, 1997, pp. 1649-1656.
“A Novel Design for an Electrospray/Time-of-Flight Mass Spectrometer”, article written by Jacqueline C. Fabbi et al., p. 51.
“A Novel Ion Funnel for Focusing Ions at Elevated Pressure Using Electrospray Ionization Mass Spectrometry”, article written by Scott A. Shaffer et al. forRapid Communications in Mass Spectrometry, vol. 11, pp. 1813-1817.
“A Segmented Radiofrequency-Only Quadrupole Collision Cell for Measurements of Ion Collision Cross Section on a Triple Quadrupole Mass Spectrometer”, article written by Gholamreza Javahery et al. forAmerican Society for Mass Spectrometry, 1997, pp. 697-702.
“An Atmospheric Pressure Ion Lens That Improves Nebulizer Assisted Electrospray Ion Sources”, article written by Bradley R. Schneider et al., forAmerican Society for Mass Spectrometry, 2002.
“An Atmospheric Pressure Ion Lens to Improve Electrospray Ionization at Low Solution Flow-Rates”, article written by Bradley R. Schneider et al. forRapid Commun. Mass Spectrom, 2001, pp. 2168-2175.
“Capillary Zone Electrophoresis-Mass Spectrometry Using an Electrospray Ionization Interface”, article written by Richard D. Smith et al. forAnal. Chem., 1988, pp. 436-441.
“Characterization of an Improved Electrodynamic Ion Funnel Interface for Electrospray Ionization Mass Spectrometry”, article written by Scott A. Shaffer et al., forAnal. Chem., 1999, pp. 2957-2964.
“Collisonal Focusing Effects in Radio Frequency Quadrupoles”, article writted by D. J. Douglas et al. forAmerican Society for Mass Spectrometry, 1992, pp. 398-408.
“Design and Implementation of a New Electrodynamic Ion Funnel”, article written by Taeman Kim et al., forAnal. Chem., 2000, pp. 2247-2255.
“Electrified Droplet Fission and the Rayleigh Limit”, article written by Daniel C. Taflin et al. forLangmuir, 1989, pp. 376-384.
“Electrospray Interface for Liquid Chromatographs and Mass Spectrometers”, article written forAnal. Chem., 1985, pp. 675-679.
“Electrospray Ion Source. Another Variation on the Free-Jet Theme”, article written forJ. Phys Chem., 1984, pp. 4451-4459.
“Electrospray Ionization for Mass Spectrometry of Large Biomolecules”, article written forScience, vol. 246, Oct. 6, 1989, pp. 64-70.
“Electrospray Ionization Time-of-Flight Mass Spectrometric Detection for Fast Liquid Phase Separations”, article written by Julia M. Lazar et al. forAmerican Laboratory, Feb. 2000, pp. 110-119.
“Improved Transmission From Atmospheric Pressure to High Vacuum Using a Multicapillary Inlet and Electrodynamic Ion Funnel Interface”, written by Taeman Kim et al. forAnal. Chem, 2000, pp. 5014-5019.
“Incorporation of a Venturi Device in Electrospray Ionization”, article written by Li Zhou et al., forAnal. Chem., 2003, pp. 5978-5983.
“Macrocyclic Chemistry in the Gas Phase: Intrinsic Cation Affinities and Complexation Rates for Alkali Metal Cation Complexes of Crown Ethers and Glymes”, article written by In-Hou Chu et al. for theAmerican Chemical Society, 1993, pp. 5736-5744.
“Mass Spectrometry”, article written by A.L. Burlingame et al. forAnal. Chem., 1998, pp. 647-716.
“Matrix Effect on the Analysis of Oligonucleotides by Using a Mass Spectrometer With a Sonic Spray Ionization Source”, article written by Min Huang, et al. forAnalytical Sciences, Oct. 2001, vol. 17, pp. 1179-1182.
“Multi-Charged Oligonucleotide Ion Formation in Sonic Spray Ionization”, article written by Min Huang et al. forAnalytical Sciences, Apr. 2002, vol. 18, pp. 385-390.
“Nano-Electrospray Ionization Mass Spectrometry: Addressing Analytical Problems Beyond Routine”, article written by M. Karas et al. forPresenius J Anal. Chem, 2000, pp. 669-676.
“On Cluster Ions, Ion Transmisson, and Linear Dynamic Range Limitations in Electrospray (Ionspray) Mass Spectrometry”, article written by D. R. Zook et al.,International Journal of Mass Spectrometry and Ion Processes162, 1997, pp. 129-147.
“On-Line Mass Spectrometric Detection for Capillary Zone Electrophoresis”, article written by Mikkers et al. forAnal. Chem., 1987, pp. 1230-1232.
“Semitron® ESD 420 PEI Specifications”, product specification sheet taken from www.boedeker.com (Website for Boedeker Plastics, Inc.) Nov. 18, 2003.
“Semitron® ESD 520HR PAI Specifications”, product specification sheet taken from www.boedeker.com (Website for Boedeker Plastics, Inc.) Nov. 18, 2003.
“Sonic Spray Ionization Method for Atmospheric Pressure Ionization Mass Spectrometry”, article written by Atsumu Hirabayashi et al. forAnal. Chem., 1994, pp. 4557-4559.
“Sonic Spray Mass Spectrometry”, article written by Atsumu Hirabayashi et al. forAnal. Chem., 1995, pp. 2878-2882.
“Subatmospheric Electrospray Interface for Coupling of Microcolumn Separations With Mass Spectrometry”, article written by Frantisek Foret et al. forElectrophoresis, 2000, pp. 1363-1371.
“Zeptomole-Sensitivity Electrospray Ionization-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of Proteins”, article written by Mikhail E. Belov et al. forAnal. Chem., 2000, pp. 2271-2279.
Lee Edgar D.
Lee Milton L.
Rockwood Alan L.
Zhou Li
Brigham Young University
Lee John R.
Morriss O'Bryant Compagni P.C.
Vanore David A.
LandOfFree
Method and apparatus for aerodynamic ion focusing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for aerodynamic ion focusing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for aerodynamic ion focusing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3600221