Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Patent
1994-09-26
1997-04-15
Jones, W. Gary
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
435 71, 435 72, 435 79, 435 4, 435 6, 5363881, 530345, 530400, 422 69, 534 15, 534 16, C12Q 168, G01N 3353, C07K 200, C07K 500
Patent
active
056208502
ABSTRACT:
An article suitable for use as a biosensor includes a species of a formula X--R--Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
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Bamdad Cynthia C.
Sigal George B.
Strominger Jack L.
Whitesides George M.
Jones W. Gary
President and Fellows of Harvard College
Rees Dianne
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