Isolated human transporter proteins, nucleic acid molecules,...

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S320100, C435S325000, C435S252300, C435S254200, C435S254110, C536S023500

Reexamination Certificate

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06991920

ABSTRACT:
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.

REFERENCES:
patent: 5441875 (1995-08-01), Hediger
International Search Report Sep. 16, 2002.
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Shayakul Chairat et al. “Molecular cloning and characterization fo the vasopressin-regulated urea transporter of reat kidney collecting ducts.” Journal of Clinical Investigation, vol. 98, No. 11, 1996, pp. 2580-2587.
Bagnasco Serena M et al. “Differentaial expression of indidvidual UT-A urea transporter isoforms in rat kidney.” Jouranl of the American Society of Nephrollogy, vol. 11, No. 11, Nov. 2000, pp. 1980-1986.
Bagnasco Serena M et al. “Clonin and charaterization of the human urea transporter UT-A1 and mapping of the human S1c14a2 gene.” American Journal of Physiology, vol. 281, No. 3 Part 2, Sep. 2001, pp. F400-F406.
Sands Jeff M. “Regulation of renal urea transporters.” Journal of the American Society of Nephrology, vol. 10, No. 3, Mar. 1999, pp. 635-646.
Sands J.M.; “Regulation of urea transporter proteins in kidney and liver.” The Mount Sinai Journal of Medicine, New York, vol. 67, No. 2, Mar. 2000, pp. 112-11.

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