Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-01-31
2006-01-31
Chan, Christina (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388700
Reexamination Certificate
active
06992176
ABSTRACT:
An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA-restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.
REFERENCES:
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 3839153 (1974-10-01), Schuurs et al.
patent: 3850578 (1974-11-01), McConnell
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3853987 (1974-12-01), Dreyer
patent: 3867517 (1975-02-01), Ling
patent: 3879262 (1975-04-01), Schuurs et al.
patent: 3901654 (1975-08-01), Gross
patent: 1178116 (2002-02-01), None
patent: WO 95/29193 (1995-11-01), None
patent: WO 97/02342 (1997-01-01), None
Harlow and Lane. Antibodies, A Laboratory Manual. 1998, Cold Spring Harbor Laboratory, USA, p. 287.
Remington's Pharmaceutical Sciences 18thEdition. 1990, Gennaro, A. R., Ed., Mack Printing Co., Easton, PA, p. 1579.
Rammensee et al. MHC Ligands and Peptide Motifs. 1997, Springer, NY, pp. 235-281.
Andersen et al, “A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells”, Proc Natl Acad Sci U S A. Mar. 5, 1996;93(5):1820-4.
Chames et al, “Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library”, Proc Natl Acad Sci U S A. Jul. 5, 2000;97(14)7969-74.
Reiter et al, “Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cel receptor-like specificity”, Proc Natl Acad Sci U S A. Apr. 29, 1997;94(9)4631-6.
Cohen, et al, “Direct detection and quantitation of a distinct T-cell epitope derived from tumor-specific epithelial cell-associated mucin using human recombinant antibodies endowed with the antigen-specific, major histocompatibility complex-restricted specificity of T cells”, Cancer Res. Oct. 15, 2002;62(20):5835-44.
Denkberg Galit
Reiter Yoram
DiBrino Marianne
Technion Research & Development Foundation Ltd.
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