Pyrazole compounds useful as protein kinase inhibitors

Details Pyrazole compounds useful as protein kinase inhibitors Pyrazole compounds useful as protein kinase inhibitors

2006-01-24

2006-01-24

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S260100, C514S262100, C514S264110, C514S266230, C544S278000, C544S279000, C544S284000

Reexamination Certificate

active

06989385

ABSTRACT:
This invention describes novel pyrazole compounds of formula IIc:wherein R1is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rxand Ryare taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2and R2′are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.

REFERENCES:
patent: 5710158 (1998-01-01), Myers et al.
patent: 2001/0018436 (2001-08-01), Cushing et al.
patent: WO 00/21955 (2000-04-01), None
patent: WO 00/39101 (2000-07-01), None
patent: WO 02/18346 (2002-03-01), None
patent: WO 02/24667 (2002-03-01), None

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