Survivin-binding proteins, encoding nucleic acids, and...

Details Survivin-binding proteins, encoding nucleic acids, and... Survivin-binding proteins, encoding nucleic acids, and...

2006-05-09

2006-05-09

Ungar, Susan (Department: 1642)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S305000, C530S324000, C530S350000, C435S007100

Reexamination Certificate

active

07041783

ABSTRACT:
In accordance with the present invention, there are provided novel Survivin-binding-proteins (SBPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SBPs can be employed in a variety of ways, for example, for the production of anti-SBP antibodies thereto, in therapeutic compositions and in bioassays methods employing such proteins and/or antibodies. Also provided are transgenic non-human mammals that express the invention protein.

REFERENCES:
patent: 5968781 (1999-10-01), Yoon et al.
Colussi, PA et al, 1998, J Biol Chem, 237(41): 26566-26570.
Gottschalk, AR et al, 1996, Cell Death and Differentiation, 3(1): 113-118.
Vogel MW et al, 2002, Cerbellum, 1(4): 277-87.
Xu Xin et al, 2001, FASEB J, 15(4): A313.
Hummler E et al, 1994, PNAS, USA, 91: 5647-5651.
Gura (Science, 1997, 278:1041-1042).
Jain (Sci. Am., 1994, 271:58-65).
Curti (Crit. Rev. in Oncology/Hematology, 1993, 14:29-39).
Hartwell et al (Science, 1997, 278:1064-1068).
Bowie et al (Science, 1990, 257 : 1306-1310).
Burgess et al, (Journal of Cell Biology, 1990, 11: 2129-2138).
Lazar et al. Molecular and Cell Biology, 1988, 8: 1247-1252.
Tao. et al. The Journal of Immunology, 1989, 143(8): 2595-2601.
Gillies et al. Human Antibodies and Hybridomas, 1990, 1(1): 47-54.
Tamm I et al, 1998, Cancer Res, 58: 5315-5320.
Bourne, Y et al, 1996, Cell, 84: 863-874.
Tsai, LH et al, 1994, Nature, 371 (6496): 419-423.
WO200142451-A2 in MPSRCH search report, 2005, us-10-057-813-13.rng, pp. 3-4, and.
MPSRCH search report, 2005, us-10-057-813-14.rag, pp. 1-2.
Johnstone and Thorpe (Immunochemistry in Practice, 2nd Ed., 1987, Blackwell Scientific Publications, Oxford, pp. 49-50.
Altieri and Marchisio, “Survivin apoptosis: an interloper between cell death and cell proliferation in cancer,”Lab. Invest.79:1327-1333 (1999).
Ambrosini et al., “Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting,”J. Biol. Chem.273:11177-11182 (1998).
Ambrosini et al., “A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma,”Nat. Med.3:917-921 (1997).
Chai et al., “Structural and biochemical basis of apoptotic activation by Smac/DIABLO,”Nature406:855-862 (2000).
Du et al., “Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition,”Cell102:33-42 (2000).
Grossman et al., “Inhibition of melanoma tumor growth in vivo by survivin targeting,” Proc. Natl. Acad. Sci. USA 98(2):635-640 (2001).
Kobayashi et al., “Expression of a murine homologue of the inhibitior of apoptosis protein is related to cell proliferation,”Proc. Natl. Acad. Sci. USA96:1457-1462 (1999).
Morgan, “Principles of CDK regulation,”Nature374:131-134 (1995).
Tamm et al., “IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs,”Cancer Research58:5315-5320 (1998).
Verhagen et al., “Indentification of DIABLO, a mammalian protein that promotes apoptosis by binding to an antagonizing IAP proteins,”Cell102:43-53 (2000).
Genbank accession No.: AA313780.
Genbank accession No.: AA328484.
Genbank accession No.: AV705461.
Genbank accession No.: AW957916.
Genbank accession No.: BE790325.
Genbank accession No.: NM 017793 (gi:8923354 and gi:8923355).

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