Peptidic compounds as cysteine protease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S137000

Reexamination Certificate

active

07101880

ABSTRACT:
The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

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Yasuma, Tsuneo et al: Synthesis of Peptide Aldehyde Derivatives as Selective Inhibitors of Huma Cathepsin L and Their Inhibitory Effect on Bone Resorption Journal of Medicinal Chemistry (1988), 41(22), 4301-4308.

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