Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2006-04-11
2006-04-11
Smith, Lynette R. F. (Department: 1645)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S184100, C424S234100, C435S252300, C435S471000, C536S023100, C536S023400, C536S023700, C530S350000
Reexamination Certificate
active
07026300
ABSTRACT:
A host is immunized against infection by a strain ofChlamydiaby initial administration of an attenuated bacteria harbouring a nucleic acid encoding aChlamydiaprotein followed by administration of aChlamydiaprotein in ISCOMs. This procedure enables a high level of protection to be achieved.
REFERENCES:
patent: 5389368 (1995-02-01), Gurtiss, III
patent: 5770714 (1998-06-01), Agabian et al.
patent: 6676949 (2004-01-01), Brunham et al.
patent: 6696421 (2004-02-01), Brunham
patent: 0192033 (1986-08-01), None
patent: 98/02546 (1998-01-01), None
patent: WO 98/02546 (1998-01-01), None
patent: WO 98/10789 (1998-03-01), None
patent: WO 98/48026 (1998-10-01), None
Grayston, J.T. and S.-P. Wang. 1975. New knowledge of chlamydiae and the diseases they cause. J. Infect. Dis., 132: 87-104.
Grayston, J.T., S.-P. Wang, L.-J. Yeh, and C.-C. Kuo. 1985. Importance of reinfection in the pathogenesis of trachoma. Rev. Infect. Dis. 7:717-725.
Taylor, H.R., et al., 1982. Animal Model of Trachema. II. The importance of repeated infection. Invest. Opthalmol. Visual. Sci. 23:507-515.
Taylor, H.R., et al. 1981. An Animal Model for Cicatrizing Trachoma. Invest. Opthalmol. Sci. 21:422-433.
Caldwell, H.D., et al. 1987. Tear and serum antibody response toChlamydia trachomatisantigens during acute chlamydial conjunctivitis in monkeys as determined by immunoblotting. Infect. Immun. 55:93-98.
Wang, S.-P., et al., 1985. Immunotyping ofChlamydia trachomatiswith monoclonal antibodies. J. Infect. Dis. 152:791-800.
Nichols, R.L., et al., 1973. Immunity to chlamydial infections of the eye. VI. Homologous neutralization of trachoma infectivity for the owl monkey conjunctivae by eye secretions from humans with trachoma. J. Infect. Dis. 127:429-432.
Orenstein, N.S., et al., 1973. Immunity to chlamydial infections of the eye V. Passive transfer of antitrachoma antibodies to owl monkeys. Infect. Immun. 7:600-603.
Ramsey, KH, et al., (Mar. 1991) Resolution of Chlamydia Genital Infection with Antigen-Specific T-Lymphocyte Lines. Infect. and Immun. 59:925-931.
Magee, DM, et al., (1995). Role of CD8 T Cells in PrimaryChlamydiaInfection. Infect. Immun. Feb. 1995. 63:516-521.
Su, H. and Caldwell, HD., (1995) CD4+ T Cells Play a Significant Role in Adoptive Immunity toChlamydia trachomatisInfection of the Mouse Genital Tract. Infect. Immun. Sep. 1995, 63: 3302-3308.
Beatty, PR., and Stephens RS., (1994) CD8+ T Lymphocyte-Mediated Lysis ofChlamydia-Infected L Cells Using an Endogenous Antigen Pathway., Journal of Immun. 1994, 153:4588.
Starnbach, MN., Bevan, MJ. and Lampe, MF. (1994), Protective Cytotoxic T. Lymphocytes are Induced During Murine Infection withChlamydia trachomatis, Journal of Immun. 1994, 153:5183-5189.
Starnbach, MN, Bevan, MJ. And Lampe, MF., (1995), Murine Cytotoxic T. Lymphocytes Induced FollowingChlamydia trachomatisIntraperitonal or Genital Tract Infection Respond to Cells Infected with Multiple Serovars., Infect. & Immun. Sep. 1995, 63:3527-3530.
Igietseme, JU; (1996), Molecular mechanism of T-cell control ofChlamydiain mice: role of nitric oxide in vivo. Immunology 1996, 88:1-5.
Igietseme. JU, (1996), The Molecular mechanism of T-cell control ofChlamydiain mice; role of nitric oxide. Immunology 1996, 87:1-8.
Ward, M.E. 1992. Chlamydial vaccines—future trends. J. Infection 25, Supp. 1:11-26.
Caldwell, H.D., et al., (1981). Purification and partial characterization of the major outer membrane protein ofChlamydia trachomatis. Infect. Immun. 31:1161-1176.
Bavoil, P., Ohlin, A. and Schachter, J., (1984) Role of Disulfide Bonding in Outer Membrane Structure and Permeability inChlamydia trachomatis. Infect. Immun., 44: 479-485.
Campos, M., et al., (1995) AChlamydiaMajor Outer Membrane Protein Extract as a Trachoma Vaccine Candidate., Invest. Opthalmol. Vis. Sci. 36:1477-1491.
Zhang Y.-X., et al., (1989). Protective monoclonal antibodies toChlamydia trachomatisserovar- and serogroup-specific major outer membrane protein determinants. Infect. Immun. 57:636-638.
Zhang, Y.-X., et al., 1987. Protective monoclonal antibodies recognise epitopes located on the major outer membrane protein ofChlamydia trachomatis. J. Immunol. 138:575-581.
Department of Health and Human Services, (1989) Nucleotide and amino acid sequences of the four variable domains of the major outer membrane proteins ofChlamydia trachomatis. Report Nos: PAT-APPL-7-324664. National Technical Information Services, Springfield, VA.
Yuan, Y., et al. (1989) Nucleotide and deduced amino acid sequences for the four variable domains of the major outer membrane proteins of the 15Chlamydia trachomatisserovars. Infect. Immun. 57:1040-1049.
Su, H. and Caldwell, H.D. 1992. Immunogenicity of a chimeric peptide corresponding to T-helper and B-cell epitopes of theChlamydia trachomatismajor outer membrane protein. J. Exp. Med. 175:227-235.
Su. H., N.G. Watkins. Y.-X. Zhang and H.D. Caldwell (1990).Chlamydia trachomatis-host cell interactions: role of the chlamydial major outer membrane protein as an adhesin. Infect. Immun. 58:1017-1025.
Peeling, R., I.W. McClean and R.C. Brunham. (1984). In vitro neutralization ofChlamydia trachomatiswith monoclonal antibody to an epitope on the major outer membrane protein. Infect. Immun. 46:484-488.
Lucero, M.E. and C.-C. Kuo. (1985). Neutralization ofChlamydia trachomatiscell culture infection by serovar specific monoclonal antibodies. Infect. Immun. 50:595-597.
Baehr. W., et al. (1988) Mapping antigenic domains expressed byChlamydia trachomatismajor outer membrane protein genes. Proc. Natl. Acad. Sci. USA, 85:4000-4004.
Stephens, R.S., et al. (1988) High-resolution mapping of serovar-specific and common antigenic determinants of the major outer membrane protein ofChlamydia trachomatis. J. Exp. Med. 167:817-831.
Conlan, J.W., I.N. Clarke and M.E. Ward. (1988). Epitope mapping with solid-phase peptides: Identification of type-, subspecies-, species-, and genus-reactive antibody binding domains on the major outer membrane protein ofChlamydia trachomatis. Mol. Microbiol. 2:673-679.
Conlan, J.W., et al., (1990). Isolation of recombinant fragments of the major outer membrane protein ofChlamydia trachomatis: their potential as subunit vaccines. J. Gen. Microbial. 136: 2013-2020.
Morrison, R.P., D.S. Manning, and H.D. Caldwell. (1992). Immunology ofChlamydia trachomatisinfections. p. 57-84 In T.C. Quinn (ed) Sexually transmitted diseases. Raven Press Ltd., NY.
Kersten, G.F.A. and Crommelin, D.J.A. (1995). Liposomes and ISCOMs as vaccine formulations. Biochimica et Biophysica Acta 1241 (1995) 117-138.
Morein, B., et al., (1990) The iscom—a modern approach to vaccines seminars in Virology, vol. 1, 1990: pp. 49-55.
Mowat & Reid, 1992. Preparation of Immune Stimulating Complexes (ISCOMs) as Adjuvants. Current Protocols in Immunology 1992. Supplement 4: 2.11.1 to 2.11.12.
M.A. Liu et al. Overview of DNA vaccines. 1995. Ann. N.Y. Acad. Sci. 772:15-20.
W.M. McDonnell and F.K. Askari Molecular medicine. 1996. N.Engl. J. Med. 334:42-45.
J.B. Ulmer et al. Heterologous protection against infjuenza by injection of DNA encoding a viral protein. 1993. Science 259:1745-1749, Mar. 19.
M. Sedegah et al. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. 1994. Proc. Natl. Acad. Sci. U.S.A. 91:9866-9870.
A. Darji et al. Oral somatic transgene vaccination using attenuated S. typhimurium. 1997. Cell 91:765-775.
D.R. Sizemore, Attenuated bacteria as a DNA delivery vehicle for DNA-mediated immunization. 1997. Vaccine 15:804-807.
D. O'Callaghan and A. Charbit. High efficiency transformation ofSalmonella typhimuriumandSalmonella typhiby electroporation. 1990. Mol. Gen. Genet. 223:156-158.
R. Brunham et al.Chlamydia trachomatisfrom individuals in a sexually transmitted disease cor group exhibit frequent sequence variation in the major outer membrane protein (omp1) gene. 1994. J. Clin. Invest. 94:458-463.
R.P. Morrison et al. Gene knockout mice extablish a primary protective role for major histocompatibility complex class II-Restricted responses inChlamydia trachomatisgenital tract infection. 1995.
Brunham Robert C.
Murdin Andrew D.
Sanofi Pasteur Limited
Sim & McBurney
LandOfFree
One step immunization procedure for inducing a Chlamydia... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with One step immunization procedure for inducing a Chlamydia..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and One step immunization procedure for inducing a Chlamydia... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3587635